Browsing Colleges and Schools by Department "Neuroscience"
Now showing items 1-20 of 35
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(2018-01-23)Over 90% of spinal cord injuries are caused by traumatic accidents and are often associated with secondary tissue damage that can provide a source of continued pain input. Previous work has shown that nociceptive stimulation ...
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(2021-07-08)Age-relate cognitive decline is a devastating disorder often associated with serious neurological disease and neurodegeneration. The increased prevalence of neurological diseases, as a result of the aging population, only ...
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(2023-04-27)Patterns of resting-state functional connectivity (rsFC) following a traumatic event may reflect underlying neurobiological processes that play a critical role in the pathogenesis and recovery from posttraumatic stress ...
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(2022-10-20)Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by progressive motor dysfunction and currently has no cure. Research has elucidated coalescing molecular dysfunctions including neuroinflammation, ...
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(2022-12-10)The vertebrate auditory system evolved to detect and encode a broad range of natural sounds. In mammals, the primary auditory cortex (A1) is the terminal stage of the ascending central auditory system and is comprised of ...
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Brain Networks and Behavior in Aging Females: Impacts of Menopause, Sex Hormones, and Sleep Patterns (2022-06-07)With both healthy aging and age-related disease, there are sex differences in brain and behavioral outcomes. Collectively, the literature suggests that females experience more severe aging impacts than males. Emerging ...
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(2018-06-22)Anxiety disorders are among the most common and debilitating forms of mental illnesses in society. Through greater understanding of the fundamental mechanisms of anxiety, as well as of the factors that lead to the persistence ...
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(2018-05-09)Opioids have been utilized for millennia for analgesia, but are accompanied by numerous adverse effects in addition to their pain relief abilities. These include tolerance, opioid-induced hyperalgesia, the propensity for ...
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(2021-08-19)Metabolic-Mood Syndrome (MMS) is used to describe the comorbidity between multifactorial diet-related diseases (e.g., metabolic syndrome, cardiovascular disease) and mood disorders (e.g., major depressive disorder, anxiety). ...
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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(2016-07-28)Research on long noncoding RNAs (lncRNAs) has increased significantly over the past few decades. However, investigation of lncRNA continues to lag behind that of other noncoding RNAs species like microRNA (miRNA). One ...
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(2022-12-10)Parkinson’s disease is a multifaceted neurodegenerative disease characterized by dopamine neuron loss; but more importantly there are no know treatments for PD that can truly alter disease progression. The two major risk ...
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(2016-08-05)A defining symptom of numerous human psychopathologies is the inability to control maladaptive behaviors—or “habits.” Extensive research using animal learning paradigms has led to exciting developments regarding the ...
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(2022-06-03)The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as ...
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(2020-09-07)The dorsomedial striatum (DMS) of the basal ganglia is critically involved in drug and alcohol abuse and contains medium spiny neurons (MSNs) expressing dopamine D1 receptors (D1Rs) or D2Rs. D1-MSNs positively and D2-MSNs ...
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(2017-07-10)Sex differences in stress and anxiety disorders are well reported in the clinical population. For instance, women are twice as likely to be diagnosed with post-traumatic stress disorder (PTSD) compared to men. This difference ...
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(2020-03-18)Duchenne muscular dystrophy (DMD) is an X-linked muscle wasting disease that affects 1:3500 males at birth. Mutations in the DMD gene alter the reading frame, preventing expression of functional dystrophin protein. Dystrophin ...
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(2017-05-02)Opioids are amongst the most effective and widely prescribed medications for the treatment of pain following spinal cord injury (SCI). Spinally-injured patients receive opioids shortly upon arrival at the emergency room, ...