Browsing Colleges and Schools by Author "Sacchettini, James C."
Now showing items 1-20 of 27
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Mire, Joseph Andrew (2013-07-24)β-lactamase enzymes catalyze the irreversible hydrolysis of the four-membered cyclic amide ring characteristic of β-lactam antibiotics rendering them inactive and useless against pathogenic bacteria. Understanding structure ...
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DeJesus, Michael A. (2012-07-16)Determining which genes are essential for growth of a bacterial organism is an important question to answer as it is useful for the discovery of drugs that inhibit critical biological functions of a pathogen. To evaluate ...
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Reyes Caballero, Hermes (2012-10-19)NmtR and AdcR belong to two structural and functional classes of transcriptional metalloregulators. The present study shows that AdcR is a novel Zn(II) dependent repressor and the first ever metalloregulator of the MarR ...
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Crystallization and mutational studies of carbon monoxide dehydrogenase from moorella thermoacetica Kim, Eun Jin (Texas A&M University, 2004-09-30)Carbon Monoxide Dehydrogenase (CODH), also known as Acetyl-CoA synthase (ACS), is one of seven known Ni containing enzymes. CODH/ACS is a bifunctional enzyme which oxidizes CO to CO2 reversibly and synthesizes acetyl-CoA. ...
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Gopal, Kreshna (2009-06-02)Data preprocessing is critical for machine learning, data mining, and pattern recognition. In particular, selecting relevant and non-redundant features in highdimensional data is important to efficiently construct models ...
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Berry, Joel Dallas (2011-08-08)The purpose of the work described in this dissertation is to better understand the role of Rz and Rz1 function with respect to phage lysis. We determined using both a genetic and biochemical approach that the Rz protein ...
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Thorstad, Melissa (2013-05-23)In 1996, scientists discovered a connection between the gene for the human protein frataxin (FXN) and the neurodegenerative disease Friedreich’s ataxia (FRDA). Decreased FXN levels result in a variety of aberrant phenotypes ...
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Funck, Edward Sterling (2012-07-16)Despite an ever growing number of reports concerning the anion-π interaction, controversy surrounding the nature of these weak supramolecular interactions continues. In an effort to further explore the nature and properties ...
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Cheng, Yu-Shan (2016-07-13)Tuberculosis (TB) killed 1.5 million people and rivaled AIDS, becoming the leading cause of death from infectious disease in 2014. The prevalence of multidrug resistant TB has intensified the current therapeutic procedure, ...
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Ngwenya, Sharon Khethiwe (Texas A&M University, 2005-08-29)17β-Estradiol induces E2F-1 gene expression in ZR-75 and MCF-7 human breast cancer cells. Analysis of the E2F-1 gene promoter in MCF-7 cells previously showed that hormone-induced transactivation required interactions between ...
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Kuty, Gabriel (2012-02-14)SAR endolysins are a recently discovered class of muralytic enzymes that are regulated by dynamic membrane topology. They are synthesized as enzymatically inactive integral membrane proteins during the phage infection cycle ...
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Deaton, John Franklin (Texas A&M University, 2004-11-15)The 105aa lambda S protein is the prototype holin, S accumulates in the cytoplasmic membrane during late gene expression until, at a time programmed into its primary structure, it disrupts the membrane and allows the lambda ...
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Zhu, Wan Wen (2012-10-19)MshA is a glycosyltransferase that synthesizes the precursor of mycothiol, a low-molecular-weight thiol found exclusively in Actinomycetes, including the virulent pathogen Mycobacterium tuberculosis (Mtb). The structure ...
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Tsai, Chi-Lin (2012-07-16)Iron-sulfur (Fe-S) clusters are critical protein cofactors found in all life forms. In eukaryotes, a well-conserved biosynthetic pathway located in the mitochondria is used to assemble Fe-S clusters. Although proteins ...
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Lucumi Moreno, Edinson (Texas A&M University, 2007-04-25)Malaria is a disease that causes more than 1 million deaths per year world wide and more than 400 million clinical cases. Due to the acquired resistance of Plasmodium falciparum to the drugs used to control the infection, ...
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Dey, Sanghamitra (2009-05-15)Mycobacterium tuberculosis (Mtb) utilizes different metabolic pathways for its survival during infection. Enzymes of these pathways are often targets for antibiotic development. Genetic studies indicate the importance of ...
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Ramachandran, Rajesh (Texas A&M University, 2006-04-12)Perfringolysin O (PFO), a cytolytic toxin from by the pathogenic bacterium Clostridium perfringens, perforates mammalian cell membranes by forming large aqueous pores. Secreted as water-soluble monomers, the toxin molecules ...
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Sun, Qingan (2011-08-08)Structural biology lays the molecular foundation for the modern field of life sciences. In this thesis, X-ray crystallography is the primary resource for atomic detail structural information and is the major technology ...
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Yu, Hong (2009-05-15)Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of ...
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Yang, Dong (2009-06-02)The objective of this work is to investigate the structures of two nucleotide binding proteins: mevalonate kinase (MVK) and FtsZ. MVK is the key enzyme involved in terpenoid biosynthesis. In this study, we solved the crystal ...