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    The impact of social stress on acute Theiler's murine encephalitis virus infection.

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    etd-tamu-2003A-2003031513-1.pdf (281.1Kb)
    Date
    2004-09-30
    Author
    Johnson, Robin Ranee
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    Abstract
    Stress is known to alter immune function, both in positive and negative ways. The disparate effects of stress on immune function remains an active area of investigation. This thesis investigates how the application of social disruption stress either prior to or concurrent with infection alters the neuropathogenesis of Theiler's murine encephalitis virus. Experiment 1 verified that social disruption prior to infection exacerbated the course of infection. Experiment 2 examined application of social disruption concurrent with infection, and found that this may produce a delay in symptom onset, and possibly a protective effect. Experiment 3 directly compared the two schedules to each other. The previous findings were replicated and expanded with additional measures (both behavioral and physiological) that further verified the earlier findings. Social disruption applied prior to infection resulted in greater behavioral and physiological exacerbation of the disease. Concurrently applied stress remained protective or inhibitory in the disease progression. Timing of stress is one of several quantitative aspects of stress that has been found to impact the stress-immune interaction and should be further investigated.
    URI
    https://hdl.handle.net/1969.1/251
    Subject
    Stress
    social stress
    mice
    infection
    CNS
    inflammation
    BALB/cJ
    neuropathogenisis
    encephalitis
    virus
    behavioral
    Theiler's virus
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    • Electronic Theses, Dissertations, and Records of Study (2002– )
    Citation
    Johnson, Robin Ranee (2003). The impact of social stress on acute Theiler's murine encephalitis virus infection.. Master's thesis, Texas A&M University. Texas A&M University. Available electronically from https : / /hdl .handle .net /1969 .1 /251.

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