Peptide-Based Biogenic Products: A Conservative Approach to Treat Dental Caries

Abstract

Biogenic peptide-based dental products would allow for a greater preservation of the natural dentition, as it cannot be regrown or return to its original state. This innovative technique demonstrates extreme potential through its versatility in healthcare fields, peptide structure, mechanism of action, and application methods. Peptide-based products have been researched in medicine through the development of vaccines and rapid coagulating agents used in surgeries. In dentistry, new peptide-based restorative and remineralizing technologies are valuable and innovative resources for tooth restoration. Peptide products are shown to have statistically significant effects on treating demineralization and preventing further cavitation of enamel. Through the use of stable nano-spherical assemblies of amino acids, artificial peptides have the ability to create a foundation similar to healthy enamel, remineralizing the demineralized area. Clinical and at-home applications of these products have become more convenient methods for dental professionals and patients. Peptide-based products were compared separately and in conjunction with fluoride to assess which therapy provided superior results. The combination of peptide products with fluoride showed a stronger structural stability and aesthetic result than with peptide use alone. Further research into different application methods and effectiveness of peptides in advanced lesions is needed. A major limitation, one found in medicine, with the use of biogenic peptides was the use of virus-like particles (VLPs) in various products, potentially causing allergic reactions. Peptide products display promising results in the treatment of dental caries, thus, saving the patient time, money, and unnecessary pain.