dc.contributor.advisor | Liu, Jyh-Charn | |
dc.creator | Fu, Guoyu | |
dc.date.accessioned | 2019-10-15T16:02:56Z | |
dc.date.available | 2021-05-01T12:34:20Z | |
dc.date.created | 2019-05 | |
dc.date.issued | 2019-02-18 | |
dc.date.submitted | May 2019 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/184384 | |
dc.description.abstract | Jmjd3, a histone H3K27 demethylase, regulates macrophage and T-cell differentiation, but its role in T-cell trafficking and persistence remains largely unknown. In this dissertation, I show that Jmjd3 deficiency in CD4^+ T cells limits CD4^+ T-cell egress out of the thymus, leading to thymic T-cell accumulation, and Jmjd3 deletion limits peripheral CD4^+ T-cell migration, leading to a reduced number of T cells in secondary lymphoid organs. Further investigation identified Pdlim4 as a novel Jmjd3 target gene that affects T-cell trafficking by cooperating with S1P1. Jmjd3 deficiency also enables T-cell persistence due to an increase in proliferation and a decrease in apoptosis, suggesting that the H3K27 demethylase Jmjd3 may be a good therapeutic target for adoptive immunotherapy for the generation of superior T cell grafts. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.subject | GNSS | en |
dc.subject | GPS | en |
dc.subject | geometry | en |
dc.subject | signal | en |
dc.subject | parameterization | en |
dc.subject | coverage | en |
dc.subject | TDOA | en |
dc.title | Z-Curve: A Time Difference of Arrivals (TDOA) Based Model for Global Navigation Satellite Systems (GNSS) Signals | en |
dc.type | Thesis | en |
thesis.degree.department | Computer Science and Engineering | en |
thesis.degree.discipline | Computer Engineering | en |
thesis.degree.grantor | Texas A & M University | en |
thesis.degree.name | Doctor of Philosophy | en |
thesis.degree.level | Doctoral | en |
dc.contributor.committeeMember | Bettati, Riccardo | |
dc.contributor.committeeMember | Stoleru, Radu | |
dc.contributor.committeeMember | Bishop, Michael | |
dc.type.material | text | en |
dc.date.updated | 2019-10-15T16:02:56Z | |
local.embargo.terms | 2021-05-01 | |
local.etdauthor.orcid | 0000-0002-6395-3664 | |