| dc.creator | Monikis, Dmitrios | |
| dc.creator | Floudas, Christodoulos | |
| dc.creator | Woodruff, Trent | |
| dc.creator | Cooper, Matthew A. | |
| dc.creator | Croker, Daniel E. | |
| dc.creator | Monk, Peter, N. | |
| dc.date.accessioned | 2019-09-11T17:15:27Z | |
| dc.date.available | 2019-09-11T17:15:27Z | |
| dc.date.issued | 2019-05-07 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/177845 | |
| dc.description.abstract | A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1). In some cases, the compound is peptide P32 or P59. Methods of recruiting β-arrestin 2 in a cell, modulating C5a-induced ERK1/2 activation in a macrophage, selectively inhibiting the release of IL-6 from a macrophage, are also provided. | en |
| dc.language | EN | |
| dc.publisher | United States. Patent and Trademark Office | |
| dc.rights | Public Domain (No copyright - United States) | en |
| dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
| dc.title | Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands | en |
| dc.type | Utility patent | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.description.country | US | |
| dc.contributor.assignee | The Regents of the University of California | |
| dc.contributor.assignee | The Texas A&M University System | |
| dc.contributor.assignee | The University of Queensland | |
| dc.contributor.assignee | University of Sheffield | |
| dc.identifier.patentapplicationnumber | 15/295979 | |
| dc.date.filed | 2016-10-17 | |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.subject.cpcprimary | C07K 7/06 | |
| dc.subject.cpcprimary | A61K 38/00 | |
