dc.creator | Hillman, Jeffrey D. | |
dc.creator | Smith, James Leif | |
dc.creator | Wilson-Stanford, Shawanda R. | |
dc.date.accessioned | 2019-06-17T17:14:17Z | |
dc.date.available | 2019-06-17T17:14:17Z | |
dc.date.issued | 2018-05-08 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/177246 | |
dc.description.abstract | The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of antibiotics wherein the amino acid at position (1) is changed to Ile or Gly, the amino acid at position (4) is changed to an Ala, the amino acid at position (4) is removed, the amino acid at position (5) is changed to an Ala, or wherein, as in the case of MU1140, the amino acid at position (13) is Arg, the Arg at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Variants of the lantibiotic MU1140 and other lantibiotics with improved pharmacological properties and structural features | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | Oragenics, Inc. | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 14/381420 | |
dc.date.filed | 2013-02-22 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | C07K 14/195 | |
dc.subject.cpcprimary | A01N 25/34 | |
dc.subject.cpcprimary | A01N 63/02 | |
dc.subject.cpcprimary | A23G 4/123 | |
dc.subject.cpcprimary | A23L 2/52 | |
dc.subject.cpcprimary | A61K 8/64 | |
dc.subject.cpcprimary | A61K 8/99 | |
dc.subject.cpcprimary | A61K 35/744 | |
dc.subject.cpcprimary | A61K 38/164 | |
dc.subject.cpcprimary | A61K 39/09 | |
dc.subject.cpcprimary | A61K 45/06 | |
dc.subject.cpcprimary | A61Q 11/00 | |
dc.subject.cpcprimary | C07K 14/315 | |
dc.subject.cpcprimary | C12N 9/0006 | |
dc.subject.cpcprimary | A23V 2002/00 | |
dc.subject.cpcprimary | A61K 38/12 | |
dc.subject.cpcprimary | A61K 39/02 | |
dc.subject.cpcprimary | A61K 2800/74 | |
dc.subject.cpcprimary | C12Y 101/01001 | |
dc.subject.cpcprimary | A61P 1/02 | |
dc.subject.cpcprimary | A61P 31/04 | |
dc.subject.cpcprimary | A01N 63/10 | |
dc.subject.cpcprimary | Y02A 50/30 | |
dc.subject.cpcprimary | Y02A 50/473 | |