Compositions and methods for drug-sensitization or inhibition of a cancer cell
Abstract
The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly inhibit them. The disclosure also provides methods of administering such compositions to increase reactive oxygen species (ROS), particularly superoxides, in cancer cells. The disclosure further provides methods of determining whether a cancer will respond to chemotherapeutics and whether to administer rifamycin or a rifamycin derivative based on ROS levels in cancer cells of a patient.
Subject
G01N 33/84A61K 31/122
A61K 31/136
A61K 31/337
A61K 31/395
A61K 31/435
A61K 31/475
A61K 31/4745
A61K 31/5377
A61K 31/573
A61K 31/675
A61K 31/69
A61K 31/704
A61K 31/7068
A61K 33/24
A61K 38/08
A61K 45/06
C07D 498/22
G01N 33/582
G01N 2800/52
Collections
Citation
Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (2015). Compositions and methods for drug-sensitization or inhibition of a cancer cell. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177117.