Perlecan domain V protects, repairs and restores ischemic brain stroke injury and motor function
Abstract
The disclosed invention relates to the use of perlecan domain V (DV) for the treatment of stroke, traumatic brain injury (TBI) or spinal cord injuries (SCI). In certain embodiments, fusion proteins of DV can be used for the treatment of stroke, TBI or SCI. DV is also referred to as endorepellin in the art. This application also provides compositions and combination therapies for the treatment of stroke, TCI and/or SCI. Another aspect of the invention provides methods of restoring motor function in subjects having neurological damage arising from a stroke, TBI or SCI.
Subject
A61K 38/2006A61K 31/727
A61K 38/177
A61K 45/06
A61K 2300/00
C07K 16/2842
C07K 2317/75
C07K 2317/76
C07K 2317/34
Collections
Citation
Bix, Gregory J. (2015). Perlecan domain V protects, repairs and restores ischemic brain stroke injury and motor function. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177107.