Cancer treatment targeting non-coding RNA overexpression
Abstract
Provided herein are methods directed to modulating the pro-oncogenic effects of noncoding RNAs (ncRNAs) through their interactions with specificity protein transcription factors (SpTFs). In one aspect, the disclosure provides a method of inhibiting growth of a cell, such as a transformed or cancer cell, characterized by overexpression of at least one specificity protein (Sp)-regulated ncRNA and expression of at least one Sp transcription factor (SpTF), the method comprising contacting the cell with an effective amount of an SpTF agent. In some embodiments, the ncRNA is a long noncoding RNA (lncRNA). In some embodiments, the ncRNA is a microRNA (miR). Also provided are methods of treating a cell proliferative disease, predicting the response of a subject to SpTF agent-based treatment, and monitoring the efficacy of a SpTF agent-based treatment in a subject.
Subject
514/44536/23.1
536/24.5
435/325
C12Q 1/6876
A61K 31/196
A61K 33/36
C12N 15/113
A61K 31/19
A61K 31/426
A61P 35/00
A61K 45/06
A61K 31/7088
A61K 31/277
A61K 31/713
A61K 31/192
A61K 31/616
A61K 31/357
A61K 31/713
A61K 2300/00
Collections
Citation
Safe, Stephen; Kim, Kyounghyun (2015). Cancer treatment targeting non-coding RNA overexpression. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177094.