dc.creator | Romo, Daniel | |
dc.creator | Cho, Sung Wook | |
dc.creator | Smith, Jeffrey W. | |
dc.creator | Richardson, Robyn D. | |
dc.date.accessioned | 2019-06-17T17:06:04Z | |
dc.date.available | 2019-06-17T17:06:04Z | |
dc.date.issued | 2012-02-21 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176978 | |
dc.description.abstract | Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Belactosin derivatives as therapeutic agents/biological probes and their synthesis | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 11/775154 | |
dc.subject.uspcprimary | 514/279 | |
dc.subject.uspcother | 546/37 | |
dc.date.filed | 2007-07-09 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | C07D 305/12 | |
dc.subject.cpcprimary | C07D 407/12 | |
dc.subject.cpcprimary | A61P 35/00 | |