dc.creator | Ibey, Bennett L. | |
dc.creator | Yadavalli, Vamsi K. | |
dc.creator | Rounds, Rebecca M. | |
dc.creator | Beier, Hope T. | |
dc.creator | Cote, Gerard L. | |
dc.creator | Pishko, Michael V. | |
dc.date.accessioned | 2019-06-17T17:05:51Z | |
dc.date.available | 2019-06-17T17:05:51Z | |
dc.date.issued | 2012-01-03 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176969 | |
dc.description.abstract | This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecule and a functionalized polymer or nano-particle ligand present throughout the matrix of a hydrogel to interact in a glucose-dependent manner to produce an optical signal resulting from quenching of a first fluorophore linked to the ligand or sugar-binding molecule and having a fluorescent emission spectrum quenched upon binding or release of glucose. Next the first fluorophore may be excited with light of a certain wavelength. Then at least one wavelength of light in the glucose-dependent optical signal from the fluorophore may be detected with a detector to produce a detected light signal, which may be processed to produce a glucose metric, such as a glucose concentration metric. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Method for glucose monitoring using fluorescence quenching | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 12/660884 | |
dc.subject.uspcprimary | 435/14 | |
dc.date.filed | 2010-03-05 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | C12Q 1/54 | |
dc.subject.cpcprimary | G01N 33/54366 | |
dc.subject.cpcprimary | G01N 33/53 | |
dc.subject.cpcprimary | A61P 3/10 | |