Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
Abstract
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
Subject
424/139.1424/130.1
424/141.1
424/143.1
424/150.1
424/163.1
424/164.1
424/165.1
424/178.1
424/278.1
530/387.1
C07K 14/31
C07K 14/315
C07K 14/3156
C07K 16/1267
A61K 39/00
A61K 2039/505
Y10S 930/29
Collections
Citation
Xu, Yi; Hook, Magnus A. O. (2007). Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176839.