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Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use
(United States. Patent and Trademark Office, 2012-02-28)
The present invention provides MSCRAMM® proteins from S. aureus which are putative highly-expressed antigens from methicillin-resistant S. aureus, including communit-associated MRSA (CA-MRSA), and these antigens can thus ...
Beta-lactone compounds
(United States. Patent and Trademark Office, 2012-09-04)
The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof:
wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group ...
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
(United States. Patent and Trademark Office, 2012-10-02)
The present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen ...
Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative
(United States. Patent and Trademark Office, 2012-12-18)
Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.