BRILLOUIN SCATTERING SPECTROSCOPY AND MICROSCOPY: TECHNIQUES AND APPLICATIONS
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Brillouin Spectroscopy is a widely used optical technique for material characterization and analysis. Recent studies suggest that Brillouin spectroscopy can be extended into an imaging modality, which would present with a wide range of applications in the study of biomechanics, stem cell differentiation, and cancer diagnostics. Extending this technology to microscopy would represent a significant advancement in optical imaging technology, in addition to a substantial capacity for commercialization. We show the potential use of Brillouin spectroscopy as a diagnostic tool for bacterial meningitis, improve the Brillouin spectrum using molecular absorption cells to filter elastically scattered photons, and develop existing Brillouin spectroscopy technology into imaging with Brillouin microscopy to create two-dimensional images of soft tissue on the micro-scale by the tissue’s bulk modulus or compressibility. In this way, we offer a method by which microscopic changes in the solid mechanical properties of tissue can be monitored, leading to a better understanding of the ways in way forces direct biological tissue to differentiate and change.
Steelman, Zachary A (2014). BRILLOUIN SCATTERING SPECTROSCOPY AND MICROSCOPY: TECHNIQUES AND APPLICATIONS. Undergraduate Research Scholars Program. Available electronically from