Browsing by Subject "tissue engineering"
Now showing items 1-20 of 20
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(2006-07-11)The process of viral infection has been shown to be a tightly structured process that exerts precise control over the nucleus. By quantitatively documenting the dynamic nuclear changes in response to nuclear infection of ...
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(2018-11-08)Tissue engineering strategies incorporate cells and bioactive cues within a synthetic scaffold to mimic the biophysical and biochemical properties of native tissue to regenerate or repair damaged tissues and organs. A major ...
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(2014-03-28)Each year, millions of patients undergo reconstructive surgery to treat injuries caused by trauma, deformities, or tumor resection. Repair of these defects often requires the use of tissue grafts to promote healing. Current ...
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Characterization of Engineered Tissue by Multimodal Optical Imaging and Biaxial Mechanical Testing (2014-04-28)To better understand the relationships between mechanical stimuli and cellular responses, we developed a 3D tissue bioreactor coupling to both a biaxial mechanical testing platform and a stage for multimodal microscopy. ...
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(2020-04-13)Tissue engineered 3D cell culture models have shown promise investigating the influence of the tumor microenvironment on cancer cell behavior. Synthetic hydrogels, such as those made from poly(ethylene glycol) (PEG), can ...
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(2014-08-25)Injectable bone grafts are space-filling materials that integrate with native bone to repair large defects from congenital deformities, trauma, and tumor resection. However, current injectable bone grafts limit healing due ...
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(2017-06-06)Tissue grafts are often crucial in restoring function and promoting healing after traumatic injury. Many synthetic materials have been developed, but these often suffer from inadequate tissue integration, limited ...
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(2016-08-22)Craniofacial reconstruction surgeries are extremely challenging because of the complex anatomy of the region and its proximity to the vital tissues. These surgeries usually require custom implants. Fabrication of a custom ...
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(2012-05-02)Tissue engineering is an interdisciplinary field that aims to restore, maintain, or improve tissue function. Cells are incorporated into a scaffold that acts as a niche for the cells while they proliferate and differentiate ...
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(2018-04-27)The goal of the work described herein was to initiate development of new theoretical and experimental tools specifically designed to improve bio-fidelity in the mechanical performance of tissue-engineered constructs. Of ...
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(2019-12-12)Three-dimensional (3D) bioprinting is emerging as a promising method for rapid fabrication of biomimetic cell-laden constructs for tissue engineering using cell-containing hydrogels, called bioinks, that can be cross-linked ...
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(2020-11-10)Tissue engineering holds much promise for treatment of large bone defects. The objective of the work presented herein describes the manipulation of progenitor cells known as mesenchymal stromal cells (MSCs) and three-dimensional ...
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(2017-04-28)Poly(ε-caprolactone) (PCL) has been previously studied as a thermoresponsive shape memory polymer (SMP) for numerous biomedical applications due to its biocompatibility and biodegradability. We have previously investigated ...
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(2019-11-21)Click chemistry reactions have become an important synthetic tool for fabrication of user-defined hydrogels consisting of poly(ethylene glycol) (PEG) and bioactive peptides/proteins for tissue engineering. In this work, ...
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(2021-07-12)Periodontal regeneration is still extremely challenging because of the complexity of the anatomy and various conditions of patients. Tissue engineering may provide an approach to reconstruct the tissue structures and ...
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(2012-07-16)In the US alone, more than 500,000 coronary artery bypass procedures are performed annually. Tissue engineering shows the potential to construct functional grafts to overcome the limited availability of autologous saphenous ...
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(2020-11-13)A synthetic materials-guided approach, wherein the scaffold’s chemical and physical properties alone instruct cellular behavior for tissue regeneration, has the potential to repair clinically pervasive osteochondral defects ...
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(2022-01-12)Herein, the discovery and application of a novel class of supramolecular secondary interactions between the cycloaddition products of the inverse electron-demand Diels Alder (IEDDA) tetrazine-norbornene click reaction is ...
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(2016-08-05)Tissue engineering is a promising treatment strategy for osteochondrosis and osteoarthritis induced articular cartilage injuries, with the goal of restoring structure and function, reducing/eliminating clinical signs, and ...
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(2012-07-16)There are more than 150,000 anterior cruciate ligament reconstructions each year with the goal of recovering the balance between knee stability and mobility. As many as 25 percent of these procedures will end in joint ...