Browsing by Subject "p53"
Now showing items 1-6 of 6
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(2018-05-01)Female breast cancer (BrCa) is the most common noncutaneous cancer among women in the United States. Human epidemiological studies reveal that p53 codon 72 single nucleotide variants, encoding proline (P72) or arginine ...
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(2012-10-19)Hormone replacement therapy and estrogen replacement therapy have shown the ability to reduce risk of colon cancer development in clinical and animal studies, but in vitro research has been unable to reproduce an estradiol ...
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(2015-11-19)Estrogen is a female sex hormone that has a variety of biologic actions via modulation of gene expression through estrogen receptors (ERs). The protective effect of estradiol (E2) and estrogen signaling in colon cancer has ...
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(2011-02-22)The objective of the project is to use the RICS analysis technique in complement with confocal microscopy to determine the diffusion coefficient of the selectively labeled green fluorescent protein (GFP), GFP-EGFR and ...
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Previous studies have shown a correlation between estradiol (E2) levels in women and the decreased risk of colon cancer. E2 serves a protective role in the colon by increasing apoptosis in non-malignant colonocytes that ...
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(2009-05-15)In the studies described in this dissertation, we investigated the roles of p53 in normal development, teratogen-induced apoptosis, and birth defects. In the first study, the activation of p53 and its target genes, p21, ...