Browsing by Subject "hindlimb unloading"
Now showing items 1-8 of 8
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(2012-07-11)The effect of partial gravity (G) (as on the Lunar surface) on weightbearing bone remains undefined; a new model (the partial G mouse) provides for graded reductions in weightbearing. It was hypothesized that mice exposed ...
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(2012-07-16)NASA goals include long-term International Space Station (ISS) missions and the ambitious objective of eventually sending astronauts to Mars. Unfortunately, exposure to unloading due to microgravity during spaceflight has ...
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(2017-05-08)Microgravity-related bone loss in astronauts is a well-known consequence of space travel. These losses are a result of the catabolic reaction of the skeleton to unloading. Anti-catabolics like bisphosphonates (BPs) have ...
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(2012-10-19)Long duration spaceflight missions out of lower earth orbit, back to the lunar surface, or possibly to Mars highlight the importance of preserving muscle mass and function. Muscle atrophy occurs within days of exposure to ...
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(2020-04-10)The purpose of our study was to investigate the effects of a single period of bisphosphonate (BP) treatment on bone loss resulting from multiple periods of simulated microgravity. We hypothesized that the protective effects ...
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(2013-04-29)Mechanical unloading has deleterious effects on the musculoskeletal system and results in significant reductions in bone density, mass, and strength, which do not fully recover even years after returning to weightbearing. ...
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(2020-01-06)Osteoporosis-induced bone fractures affect approximately 2.6 million people in the United States, with over US$ 19 billion in related healthcare expenditures. Most of these patients live with this chronic condition, but ...