Browsing by Subject "Transcription"
Now showing items 1-7 of 7
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(2017-07-12)The Drosophila circadian oscillator controls daily rhythms in physiology, metabolism and behavior via transcriptional feedback loops. CLOCK-CYCLE (CLK-CYC) heterodimers initiate feedback loop function by binding enhancer ...
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(2020-10-16)The Mediator complex, consisting of the head, middle, tail and CDK8 (Cyclin-Dependent Kinase 8) kinase module, is required by almost all the protein coding gene and a variety of non-coding gene transcription in eukaryotic ...
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(2012-02-14)Understanding the mechanisms that regulate gene expression is a major challenge in biology. One of the most important tasks in this challenge is to identify the transcription factors binding sites (TFBS) in DNA sequences. ...
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(2017-07-28)Gene transcription by RNA polymerase II (Pol II) is an essential process. Using Saccharomyces cerevisiae as a model system, our lab has previously identified and partially characterized Pol II activity mutants that can ...
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(2009-06-02)Estrogen receptor (ER) acts as a ligand-activated transcription factor that regulates the expression of genes. The genomic mechanisms of ER action include ligand-induced dimerization of ER which binds estrogen responsive ...
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(2009-05-15)Eukaryotic transcriptional activators stimulate transcription of genes otherwise expressed at low levels. The typical activator operates by binding to specific sites on DNA with its activating region contacting the ...
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(2020-08-19)Zinc Finger Protein 143 (ZNF143) is a ubiquitous C2H2 zinc-finger transcriptional activator in vertebrates. Predicted to regulate over 2000 promoters, ZNF143 activates transcription at both protein coding genes and small ...