Browsing by Subject "Rotavirus"
Now showing items 1-3 of 3
-
Mapping of the rotavirus nonstructural protein-4-caveolin-1 binding site to three hydrophobic residues within the extended, c-terminal amphipathic alpha helix
(2009-05-15)Rotavirus NSP4, the first described viral enterotoxin, localizes to the plasma membrane of infected cells, possibly through interaction with caveolin-1. A direct interaction between NSP4 and caveolin-1, the structural ... -
PURIFICATION OF THE ROTAVIRUS NSP4 ENTEROTOXIN AND DISCERNMENT OF KEY HOST-CELL INTERACTIONS THAT CONTRIBUTE TO NSP4 SECRETION FROM THE CELL
(2011-05-04)Rotavirus (RV) is a viral pathogen that infects everyone worldwide. It initially infects the enterocytes of the small intestine causing severe diarrhea in affected patients, primarily the young. RV nonstructural protein 4 ... -
Rotavirus NSP4 in extrareticular sites: support for its pathogenic role as an enterotoxin
(2009-05-15)Rotavirus non structural protein 4 (NSP4) was initially characterized as an endoplasmic reticulum intracellular receptor. Continued studies of NSP4 revealed additional functions performed by or dependent on NSP4, some of ...