Browsing by Subject "Nck"
Now showing items 1-6 of 6
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Modulation of Endothelial Cytoskeletal Dynamics and YAP Localization by Angiogenic Factors
(2017-05-05)Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a crucial role in physiological processes and various pathological conditions including cancer. Angiogenic factor stimulation, including ... -
Modulation of Transforming Growth Factor β-induced Endothelial-Mesenchymal Transition by Nck
Fibrotic disorders, including atherosclerosis, are known to concur with endothelial-to-mesenchymal transition (EndMT) induced by cues from the tissue microenvironment such as transforming growth factor β (TGF-β). Nck, a ... -
Regulation of Tumor Vascular Perfusion and Permeability by Endothelial Nck
(2020-04-30)Tumor progression and metastasis is increased by the unique vasculature found in tumors which can be characterized as having low perfusion and increased permeability. The role of Nck proteins is to control actin cytoskeletal ... -
THE ROLE OF Nck ADAPTORS IN ENDOTHELIAL CELL POLARITY
(2012-05-08)The establishment of a polarized endothelial layer is essential for normal vascular organization. This project examined the role of actin cytoskeleton remodeling by Nck adaptors in the polarized organization of endothelial ... -
Role of Nck adaptors in the regulation of endothelial cell-cell adhesion
(2011-08-08)The establishment of endothelial cell-cell contacts is critical for the development and maintenance of the vascular network. Endothelial cell adherens junctions (AJ) are cell-cell adhesion complexes consisting of clusters ... -
The Role of Nck in Breast Carcinoma Cell Invasion and Metastasis
(2015-07-15)The high incidence of invasive breast carcinomas, which accounts for about 90% of all breast cancer-related deaths, underscores the need for new and more effective therapeutic approaches to block the development of the ...