Browsing by Subject "Mycobacterium tuberculosis"
Now showing items 1-20 of 20
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TnSeq is a genetic method used to evaluate the essentiality of genes in bacteria, such as Mycobacterium tuberculosis. It uses random insertions by the Himar1 transposon and high throughput sequencing to determine the most ...
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(2022-02-02)Our understanding of gene essentiality in Mycobacterium tuberculosis (Mtb) has improved over the years. The introduction of these gene products into target-based drug discovery campaigns depends, in part, on whether or not ...
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(Texas A&M University. Libraries, 1992)Previous in vitro studies of the cellular immune response to mycobacteria have used live or dead avirulent organisms or purified products of Mycobacterium tuberculosis as the antigen source. The use of live virulent ...
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(2017-12-05)The rapid emergence of drug-resistant Mycobacterium tuberculosis (Mtb) coupled to the high incidence of HIV-Mtb coinfection is of global concern. Consequently, there is a worldwide necessity to develop new drugs with novel ...
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(2021-07-26)In the era of high-throughput drug discovery against enzyme targets, the utilization of rational drug design principles has become a path less traveled. This rational approach can provide researchers more intuitive methods ...
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(2019-04-19)Combating the persistent threat and low therapeutic success of treating multidrug-resistant Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, demands a worldwide effort to discover and develop new ...
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(2008-08-03)The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which ...
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(2018-11-02)The methylcitrate cycle and glyoxylate bypass are two critical pathways of the central carbon metabolism of the human pathogen Mycobacterium tuberculosis (Mtb). Transcription of the key enzymes in these pathways is controlled ...
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(2021-04-14)Mycobacterial species contain some of the most dangerous human pathogens described throughout history, responsible for millions of deaths each year. Interestingly, many mycobacteria can infect and replicate in one of our ...
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(2021-04-19)The innate immune system is a rapid response system that functions to prevent, recognize and limit infection by responding to danger signals such as those associated with bacterial pathogens. Macrophages, a type of innate ...
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(Texas A&M University, 2005-02-17)Tuberculosis is the second leading cause of morbidity and mortality worldwide due to an infectious disease. Development of a new tuberculosis (TB) vaccine would be facilitated by a better understanding of the mechanisms ...
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(2022-11-30)The innate immune response is primarily carried out by phagocytic macrophage cells, which are designed to remove infected and dying cells to protect the host. Macrophages receive thousands of different signals, activating ...
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(2012-10-19)MshA is a glycosyltransferase that synthesizes the precursor of mycothiol, a low-molecular-weight thiol found exclusively in Actinomycetes, including the virulent pathogen Mycobacterium tuberculosis (Mtb). The structure ...
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(2012-12-03)This dissertation uses two different approaches to the identification of inhibitors of Mycobacterium tuberculosis (Mtb) - a structure-based drug discovery approach and a high-throughput screening of natural product libraries ...
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(2014-03-21)Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate (3DHS) to shikimate (SKM) utilizing NADPH cofactor in the shikimate pathway, a central route for biosynthesis of aromatic ...
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(2014-04-01)Mycobacterium tuberculosis (Mtb) is a deadly pathogen that causes the infectious diseases Tuberculosis (TB) in humans. The emergence of drug resistant TB has created an urgent need for the development of new chemotherapeutics ...
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(2013-08-09)Tuberculosis and malaria are among the most deadly infectious diseases in the world. The prevalence in regions without well-established public health causes economical and financial burdens for both society and patients. ...
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(2018-05-02)Antibacterial drug resistance is a major factor in the increasing rate of failure to successfully treat diseases such as tuberculosis (TB). The World Health Organization estimates that in 2015 a total of 10.4 million new ...
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(2016-07-29)A key determinant of the pathogenicity of M. tuberculosis (Mtb) is its ability to conserve energy and resources by altering its intermediate metabolism response to host-derived hostile conditions. Growing evidence supports ...
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(2020-04-17)TRIM (tripartite motif) family proteins are distinguished as important players in the innate immune response to infection. TRIM14 has been heavily implicated in anti-viral innate immune signaling through various protein-protein ...