Browsing by Subject "Frataxin"
Now showing items 1-5 of 5
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(2012-07-16)Iron-sulfur clusters are protein cofactors that are critical for all life forms. Elaborate multi-component systems have evolved for the biosynthesis of these cofactors to protect organisms from the toxic effects of free ...
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(2013-05-23)In 1996, scientists discovered a connection between the gene for the human protein frataxin (FXN) and the neurodegenerative disease Friedreich’s ataxia (FRDA). Decreased FXN levels result in a variety of aberrant phenotypes ...
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(2023-05-10)Iron-sulfur-cluster (ISC) assembly occurs in both mitochondria and cytosol. Defects in mitochondrial ISC assembly can result in diseases such as Friedrich’s Ataxia which results from a deficiency in frataxin. The mechanism ...
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(2018-06-07)Iron-sulfur (Fe-S) clusters are essential cofactors and are found in all branches of life. In eukaryotes, Fe-S assembly complex is composed of NFS1, ISD11, ACP, ISCU2, and FXN subunits. NFS1 is a cysteine desulfurase that ...
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(2012-07-16)Iron-sulfur (Fe-S) clusters are critical protein cofactors found in all life forms. In eukaryotes, a well-conserved biosynthetic pathway located in the mitochondria is used to assemble Fe-S clusters. Although proteins ...