Browsing by Subject "Drosophila"
Now showing items 1-20 of 26
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(2022-01-12)Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria. The composition of commensal bacterial species can thus shift in response to changes in host dietary nutrient availability, ...
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(2018-01-17)TThe Drosophila circadian clock is comprised of transcriptional feedback loops, which control rhythmic gene expression and are also responsible for daily rhythms in physiology, metabolism and behavior. The core feedback ...
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(2017-05-09)When choosing a mate, animals evaluate the attractiveness of potential partners. Attractiveness and its perception are condition-dependent traits. Animal condition is affected by complex interactions between genetic and ...
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(2016-08-03)Circadian (~24 h) clocks regulate daily cycles in gene expression to control overt rhythms in physiology, metabolism and behavior. In Drosophila, a transcriptional feedback loop activated by CLOCK-CYCLE (CLK-CYC) complexes, ...
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(2017-07-31)In Drosophila, time-keeping is based on a ~24h transcription feedback loop, in which CLOCK-CYCLE (CLK-CYC) heterodimers activate transcription of genes encoding the feedback repressors PERIOD (PER) and TIMELESS (TIM). ...
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(1997)Neuroblasts in the central nervous system of Drosophila have been increasingly utilized as a model for stem-cell study due to their clearly defined asymmetric division pattern and ease of genetic, cellular, and molecular ...
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Effects of Sialyltransferase Mutation on Drosophila melanogaster Viability, Fertility, and Longevity (2006-07-11)Sialyltransferase and other glycosylation enzymes are emerging as important players in crucial regulatory post-translational modifications. These enzymes transfer sugars to glycoproteins and glycolipids, and may aid in ...
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(2012-10-19)Sialylation is an important carbohydrate modification of glycoconjugates, which introduces sialic acids (SA). The relatively large nine-carbon, negatively charged sugars are typically located at the termini of carbohydrate ...
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(2020-10-16)The Mediator complex, consisting of the head, middle, tail and CDK8 (Cyclin-Dependent Kinase 8) kinase module, is required by almost all the protein coding gene and a variety of non-coding gene transcription in eukaryotic ...
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(2018-08-06)This work addresses the persistence of a non-male-killing Spiroplasma strain infecting the fly Drosophila hydei under conditions where there are no apparent fitness benefits to the host. This work also addresses the potential ...
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(2011-10-21)Behavior is a complex process resulting from the integration of genetic and environmental information. Thus, the genetically tractable Drosophila melanogaster was utilized to better understand the interplay between these ...
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(2015-10-09)Post-translational modification of histones play essential roles in the transcriptional regulation of genes in eukaryotes. Methylation on basic residues of histones is regulated by histone methyltransferases and histone ...
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(2012-05-09)Cyclin-Dependent Kinase 8 (CDK8) has recently emerged as an oncoprotein that is amplified in both colorectal and melanoma cancers. The importance of CDK8 and its regulatory partner Cyclin C (CycC) is highlighted by the ...
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(2012-04-26)Drosophila melanogaster larvae have historically been targeted as favorable models for the study of chemosensation and chemosensory learning due to the relative simplicity of their neuroanatomy. Sugars are traditionally ...
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(2013-02-04)Galectins represent a group of proteins that bind β-galactosyl-containing glycoconjugates and share primary structural homology in their carbohydrate recognition domains. In mammals, galectins contribute to cell-cell ...
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(2017-12-14)In contrast to mammals, which sense sweet tasting molecules through a single, dimeric sugar taste receptor, Drosophila melanogaster use at least eight sugar gustatory receptor (Gr) proteins to recognize a range of dietary ...
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(2019-10-30)Metabolic and innate immune signaling pathways have co-evolved to elicit coordinated responses. However, dissecting the integration of these ancient signaling mechanisms remains a challenge. Using Drosophila, we uncovered ...
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(2017-07-03)Genome size varies widely across organisms with no tie to organismal complexity. While much of the variation in genome size can be attributed to accumulation of nongenic DNA, the patterns and mechanisms involved are not ...
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(2019-08-28)Defects in sialylation cause numerous human pathologies including heart disease, cancer, immune system dysfunction, and neurological abnormalities. However, the pathological mechanisms of these disorders and regulation of ...
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(2012-10-19)O-mannosylation is a specific form of glycosylation, a post-translational protein modification with O-linked mannose attached to serine or threonine residues. O-mannosylation is implicated in crucial biological processes ...