Browsing by Author "Sitcheran, Raquel"
Now showing items 1-13 of 13
-
Vandehoef, Crissie Louise (2022-01-12)Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria. The composition of commensal bacterial species can thus shift in response to changes in host dietary nutrient availability, ...
-
Saltzman, Alexander B (2013-02-04)Pervasive tumors appear to evade immune detection through manipulation of the immune response, though precisely how this occurs is not well understood. A further understanding of these details may be achieved through the ...
-
Lei, Yuanjiu (2023-05-03)Mitochondria are pleiotropic organelles central to a wide array of cellular pathways including metabolism, signal transduction, and programmed cell death. Mitochondria also play key roles in mammalian immune responses, ...
-
NF-kB Inducing Kinase (NIK) Drives Metabolic Reprogramming of Myeloid Cells in Immunity and Cancer Keeney, Justin N. (2023-07-03)Myeloid cells, part of the innate immune system, are front line host defense cells that play critical roles in inflammation and tissue repair. This functional plasticity is driven by metabolic changes that occur during ...
-
McFadden, Kassandra Nicole (2018-12-11)Glioblastomas (GBMs) are a malignant subtype of brain tumor hallmarked by a high proliferation rate, cell migration, and aggressive invasion into healthy surrounding brain tissue. The extremely invasive phenotype of GBMs ...
-
Pflug, Kathryn M (2021-11-08)NF-κB-inducing kinase (NIK), the essential upstream kinase which regulates activation of the noncanonical NF-κB pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining ...
-
Jung, Jiung (2018-05-03)NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is crucial for activation of the non-canonical NF-κB signaling pathway. Although NIK has been shown to promote tumorigenesis in ...
-
Kamradt, Michael Leo (2021-01-13)The control of cell metabolism is intimately linked to the size and shape of mitochondria, which varies significantly across cell types. Mitochondria can elongate (fuse) with other nearby mitochondria, or they can fragment ...
-
Duran, Camille L (2017-04-18)A hallmark of high grade glioma is highly aggressive, diffuse invasion into normal brain tissue, contributing to a 100% recurrence rate and resistance to current therapies. Recent efforts to determine molecular differences ...
-
Cherry, Evan Michael (2017-01-05)High-grade gliomas are an invasive and deadly brain cancer. We have shown that noncanonical NF-κB/RelB signaling can drive invasion in the aggressive mesenchymal subtype of glioma. TNF-like weak inducer of apoptosis (TWEAK) ...
-
Mousavifard, Seyedhossein (2017-05-09)A leading cause of mortality in diffuse large B-cell lymphoma (DLBCL) patients is the development of resistance to the CHOP regimen, the anthracycline-based chemotherapy consisting of cyclophosphamide, doxorubicin, ...
-
Tippelt, Sydney (2021-10-08)Hox proteins are an important class of transcription factors that regulate development of region-specific features in bilaterian animals via binding and regulation of target genes. These proteins contain a conserved DNA ...
-
Cherry, Evan M; Lee, Dong W; Jung, Ji-Ung; Sitcheran, Raquel (Molecular Cancer, 2015)