Browsing by Author "Shippen, Dorothy E."
Now showing items 1-18 of 18
-
Boltz, Kara A.; Jasti, Madhu; Townley, Jennifer M.; Shippen, Dorothy E.; Lustig, Arthur J. (PloS One, 2014)
-
Tian, Lu (Texas A&M University, 2004-09-30)Epigenetic regulation is a mechanism by which heritable changes in gene expression are controlled by chromatin status rather than primary DNA sequence. Changes in chromatin structure affect accessibility of DNA elements ...
-
Mandadi, Kranthi Kiran (2011-10-21)We previously described BT2, a BTB/POZ domain containing protein, as an activator of telomerase in Arabidopsis thaliana. In the current study, I present evidence of its interesting roles in mediating multiple hormone, ...
-
Leehy, Katherine (2013-07-26)Telomeres are the ends of linear chromosomes tasked with preventing their recognition by the DNA damage machinery and providing a mechanism to solve the end replication problem. The telomeric DNA is mostly double-stranded, ...
-
Cifuentes-Rojas, Catherine (2012-02-14)Telomerase is a highly regulated ribonucleoprotein complex that stabilizes eukaryotic genomes by replenishing telomeric repeats on chromosome ends. Defects in telomerase RNP components involving the catalytic subunit TERT ...
-
Juarez, Paul Ramon (2009-05-15)The flavoprotein spermine oxidase catalyzes the oxidation of spermine and oxygen to spermidine, 3-aminopropanol, and hydrogen peroxide. To allow mechanistic studies of the enzyme, methods have been developed to obtain large ...
-
Dhasarathy, Archana (Texas A&M University, 2006-04-12)In higher eukaryotes, DNA is packaged with histones and other proteins into chromatin. While this is important in the control of unwanted gene expression, chromatin also serves as a barrier to many vital functions in the ...
-
Halbig, Kari Michele (2009-05-15)Eukaryotic transcriptional activators stimulate transcription of genes otherwise expressed at low levels. The typical activator operates by binding to specific sites on DNA with its activating region contacting the ...
-
Renfrew, Kyle B.; Song, Xiangyu; Lee, Jung Ro; Arora, Amit; Shippen, Dorothy E.; Zhou, Jin-Qiu (PLoS Genetics, 2014)
-
Gray, Christine Elizabeth (Texas A&M University, 2006-10-30)Low level and variable transgene expression plague efforts to produce and characterize transgenic lines in many species. When transformation efficiency is high, productive transgenic lines can be generated with reasonable ...
-
Selaginella moellendorffii telomeres: conserved and unique features in an ancient land plant lineage Shakirov, Eugene V.; Shippen, Dorothy E. (Frontiers in Plant Science, 2012)
-
Yu, Hong (2009-05-15)Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of ...
-
Ren, Shuxin (Texas A&M University, 2006-04-12)Telomerase is the key enzyme synthesizing telomeric DNA in most eukaryotic organisms. In mammals, telomerase expression is abundant in the germline cells but is undetectable in most other differentiated organs. Intensive ...
-
Nelson, Andrew (2012-10-19)Telomeres form a nucleoprotein cap at the end of eukaryotic chromosomes. The telomere protein constituents repress the DNA damage response (DDR) and facilitate maintenance of terminal sequences by a specialized ribonucleoprotein ...
-
Watson, James M. (2009-05-15)Telomeres are the nucleoprotein structures that protect the ends of eukaryotic chromosomes from being recognized as DNA double-strand breaks. Telomeres are recognized by the ribonucleoprotein telomerase, a reverse transcriptase ...
-
Song, Xiangyu (2011-08-08)Telomeres are the physical ends of linear chromosomes in eukaryotes. Telomeres not only protect chromosome ends from being recognized as double-strand breaks but also maintain the chromosome terminal sequences. These ...
-
Xu, Hengyi; Nelson, Andrew D. L.; Shippen, Dorothy E.; Zhou, Jin-Qiu (PLoS Genetics, 2015)
-
Fan, Lin (Texas A&M University, 2006-08-16)The transmembrane serine receptor Tsr associates with a coupling protein, CheW, and a histidine kinase, CheA, to form a ternary complex that regulates the activity of CheA. CheA activity is inhibited by binding of L-serine ...