Browsing by Author "Rusyn, Ivan"
Now showing items 1-18 of 18
-
Cordova, Alexandra Christian (2023-05-24)Natural and manmade disasters can be large-scale sources of environmental contamination, posing risks to human, animal, and environmental health. The circumstances surrounding each scenario are unique, as are the chemical ...
-
Cordova, Alexandra Christian (2023-05-24)Natural and manmade disasters can be large-scale sources of environmental contamination, posing risks to human, animal, and environmental health. The circumstances surrounding each scenario are unique, as are the chemical ...
-
Blanchette, Alexander Daniel (2021-08-25)Cardiovascular disease is a major cause of morbidity and mortality worldwide, but there is little knowledge on the potential cardiovascular effects for most environmental chemicals. Causal links to cardiovascular disease ...
-
Jang, Suji (2023-03-21)The concern of human health risks from exposure to chemicals has grown which has resulted in numerous studies in experimental animals to assess the risk. There is a significant gap in data and models as they often fail to ...
-
Popp, Julia L (2021-07-26)Contemporary approaches for developing new interventions and for pre-clinical risk evaluation include assessments for cardiovascular structure and function, frequently performed in a variety of animal and in vitro models, ...
-
Schneider, Sarah Morar (2019-04-10)Through three distinct papers, this dissertation aims to increase understanding of cardiomyopathy in golden retriever muscular dystrophy (GRMD), an important model for Duchenne muscular dystrophy (DMD). Unlike the mdx ...
-
Ferguson, Kyle Charles (2018-04-30)Application of traditional high through-put (HTP) in vitro screening, coupled with advanced mass spectrometric and separation techniques, to substances of unknown or variable composition, complex reaction products, and ...
-
Al Muhisen, Hadil Mahdi J (2023-05-10)Spermatogenesis is a crucial process that generates fertile sperm, and it is a complex process that involves a remarkable number of proteins and molecules. However, the disruption of spermatogenesis at any stage can lead ...
-
Seniutkin, Oleksii (2017-04-13)Liver fibrosis results from chronic damage and excessive regeneration with redundant accumulation of extracellular matrix proteins, including collagen. Liver fibrosis may be caused by infectious, environmental, and autoimmune ...
-
Valdiviezo, Alan Cristobal (2022-08-18)Traditional chemical screening for toxicity relies on evaluating chemicals on an individual basis. This approach has been adopted by regulatory agencies for providing chemical specific data. However, chemical exposures in ...
-
Anderson, Meredith; Valdiviezo, Alan; Conway, Mark; Farrell, Christina; Andringa, R. Keith; Janik, Amy; Chiu, Weihsueh; Rusyn, Ivan; Hamer, Sarah (2022-12-23)
-
In Vitro Models for High-Throughput Hazard, Dose-Response, and Toxicodynamic Variability Assessments Burnett, Sarah Delena (2021-08-18)Traditional drug and chemical safety testing is performed in vivo using multiple animal species, but these models are expensive, time-consuming, and low-throughput. Furthermore, poor understanding of inter-species and ...
-
Lewis, Lauren Anne (2019-12-04)Exposure to environmental and occupational chemicals can result in human disease which may be driven by genotoxicity and epigenetic alterations. In addition, genetic variants and sex-specific differences in epigenetic ...
-
Inter-individual Variability in Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene Luo, Yu-Syuan (2018-07-29)From the standpoint of public health, the purpose of chemical health risk assessment is to protect the susceptible individuals and to set up an action threshold against chemical hazards. Chemical toxicity is usually ...
-
Chen, Zunwei (2020-10-23)The lack of adequate toxicity data for the vast majority of chemicals and complex mixtures in the environment has spurred the development of new approach methodologies (NAMs) which span a vast array of in vitro and in ...
-
Aly, Noor (2021-12-06)Chemical contamination following environmental disasters profoundly effects the environment and human health. Exposure assessment is traditionally performed using Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid ...
-
Lim, Alicia Ying (2023-06-01)Traditionally, safety evaluation of drugs and chemicals is performed using in vivo animal testing. Although animal models have been thoroughly validated and have decades of accumulated data, issues such as the complexities ...
-
Lim, Alicia Ying (2023-06-01)Traditionally, safety evaluation of drugs and chemicals is performed using in vivo animal testing. Although animal models have been thoroughly validated and have decades of accumulated data, issues such as the complexities ...