Browsing by Author "Pellois, Jean-Philippe"
Now showing items 1-20 of 47
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McCormick, Sean P. (2014-12-10)Eukaryotic cells contain low-molecular-mass metal complexes (LMMMCs), defined as having masses between 200 – 10,000 Da, but these so-called labile or chelatable metal pools are poorly defined in terms of structures and ...
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Karroonnirun, Osit (2012-07-16)Biodegradable polyesters represent a class of extremely useful polymeric materials for many applications. Among these polyesters, the biodegradable and biocompatible, polylactide is very promising for many applications in ...
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Srinivasan, Divyamani; Muthukrishnan, Nandhini; Johnson, Gregory A.; Erazo-Oliveras, Alfredo; Lim, Jongdoo; Simanek, Eric E.; Pellois, Jean-Philippe; Najbauer, Joseph (PloS One, 2011)
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Erazo, Alfredo (2014-12-16)Cell-penetrating peptides (CPPs) facilitate the delivery of cell-impermeable macrmolecules across the plasma membrane of live cells. CPPs act as biological Trojan horses by hijacking and inducing endocytosis to enter cells, ...
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Whitaker, Neal William 1982- (2012-12-03)The Escherichia coli twin-arginine translocation (Tat) system transports fully folded and assembled proteins across the inner membrane into the periplasmic space. The E. coli Tat machinery minimally consists of three ...
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Kondow-McConaghy, Helena Marie (2020-06-19)Mammalian cells are a model system for biotechnology and therapeutic development. For many of these applications, some degree of cellular manipulation is required to trigger certain biological outcomes. To achieve this, ...
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Lee, Ya-Jung (2012-07-16)Cell-penetrating peptides (CPPs) mediate the delivery of macromolecules across the plasma membrane of live cells. These peptides are therefore important due to the potential of making the delivery of protein probes or ...
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Han, Junyan (2012-02-14)A xanthene-BODIPY cassette is used as a ratiometric intracellular pH reporter for imaging protein-dye conjugates in living cells. A model was hypothesized to explain the pH-dependent energy transfer efficiencies from the ...
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Millet, Agustin (2019-10-31)This dissertation focuses on the design, synthesis, and characterization of dirhodium complexes as sensitizers for dye-sensitized solar cells, as photoactivated chemotherapeutic drugs, and as photocatalysts for Hv2 production ...
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Crespo Morales, Roberto A (2017-12-05)The rapid emergence of drug-resistant Mycobacterium tuberculosis (Mtb) coupled to the high incidence of HIV-Mtb coinfection is of global concern. Consequently, there is a worldwide necessity to develop new drugs with novel ...
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Lee, Yan-Jiun (2015-12-10)Engineering of protein with new modifications essentially expands the protein functions which provide powerful tools for investigating significant biological questions. New modifications also offer scientists the ability ...
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Coll, Ryan Patrick (2021-08-04)Dirhodium complexes are used for a broad scope of applications due, in part, to the presence of a stable RhII-RhII bond which has a remarkable ability to adapt to a rich variety of ligands for the tuning of electronic and ...
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Rousseau, Simon (2021-12-09)Tuberculosis, the disease caused by the mycobacterial pathogen Mycobacterium tuberculosis, has been, prior to the COVID-19 pandemic, the world’s deadliest infectious disease. The illness has been afflicting humans for ...
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Kamat, Siddhesh (2012-10-19)Adenine deaminase (ADE) catalyzes the conversion of adenine to hypoxanthine. Mechanistic characterization of ADE from Escherichia coli was performed along with biophysical studies. The structure of ADE was solved from A. ...
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Chen, Liuxi (2012-10-19)Ion mobility spectrometry (IMS) separates ions on the basis of ion-neutral collision cross-sections (CCS, [omega]), which are determined by the geometry or conformation of the ions. The size-based IM separation can be ...
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Liu, Yongjin (2020-06-18)Nanomechanical responses of brittle materials, such as glass and ceramics, are important for various industrial applications. Understanding their deformation and failure mechanisms would offer new knowledge and help design ...
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Najjar, Kristina (2017-07-13)For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting macromolecules (cargos) into live cells for cell biology manipulations and therapeutic applications. While the exact ...
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Diaz, Joshua D (2023-06-29)Intracellular delivery agents are useful tools to introduce cargos into mammalian cells. Delivered cargos can be utilized to study biomolecules in the context of mammalian cells, to trigger a biological activity of mammalian ...
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Brock, Dakota James (2019-07-23)The effective delivery of hydrophilic, bioactive molecules, such as enzymes and nucleic acids, to the cytosol of cells has proven to be a multibillion-dollar problem for cell biologists and the pharmaceutical industry. In ...
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Muthukrishnan, Nandhini (2014-05-02)Cell-penetrating peptides (CPPs) can induce translocation of conjugated macromolecules across the plasma membrane of live cells. The major route of uptake of these CPPs by cells is through endocytosis. However, intracellular ...