Browsing by Author "Donnelly, Kirby C."
Now showing items 1-20 of 22
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Naufal, Ziad Sami (2009-05-15)Maternal exposure to genotoxic chemicals may produce a variety of adverse birth outcomes. Depending on the dose and duration of exposure, adverse birth outcomes can range from premature or low-birth weight, to congenital ...
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Yang, Wonsuk (Texas A&M University, 2006-10-30)Paraquat (PQ) is a cationic non-selective bipyridyl herbicide widely used in agriculture to control weeds and grasses. Epidemiologic studies indicate that exposure to pesticides can be a risk factor in the incidence of ...
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Roh, Hyung Keun (2010-10-12)Estrogens are a group of endocrine disrupting compounds capable of causing abnormalities in the reproductive systems of the wildlife. Wastewater is a major source of environmental estrogens, in part due to incomplete removal ...
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Shan, Yongtang (Texas A&M University. Libraries, 1993)The major hydrocarbon constituents that often contaminate groundwater resources from oil and petroleum product spills are benzene, toluene, ethylbenzene, and xylenes (BTEX). Benzene is the most toxic and most mobile ...
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Zhou, Guo-Dong; Zhu, Huiping; Phillips, Tracie D.; Wang, Jianbo; Wang, Shi-Zhou; Wang, Fen; Amendt, Brad A.; Couroucli, Xanthi I.; Donnelly, Kirby C.; Moorthy, Bhagavatula; McCormick, David L. (PloS One, 2011)
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Armstrong, Charles David (2009-05-15)Organophosphorus hydrolase (OPH, EC 3.1.8.1) is a homodimeric enzyme that has been observed to unfold via a three-state unfolding pathway (N2* ↔ I2 ↔ 2U) under chemical denaturing conditions. The dimeric intermediate (I2) ...
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Kern, Rory James (2009-05-15)There are some 15,000 known organophosphorus chemicals. Some of these OP’s, including VX and paraoxon, demonstrate an acute neurotoxicity due to the inhibition of cholinergic enzymes. Organophosphorus chemical warfare ...
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Abdel Rahim, Ma'en Ahmad (Texas A&M University, 2004-09-30)Sequence-specific small interfering RNA (siRNA) duplexes can be used for gene silencing in mammalian cells and as mechanistic probes for determining gene function. Transfection of siRNA for specificity protein 1 (Sp1) in ...
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Phillips, Tracie Denise (2009-05-15)Complex chemical mixtures are ubiquitous in the environment. Humans are frequently exposed to these mixtures; therefore, it is important to understand potential interactions of chemical mixtures. Mixture interactions may ...
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Li, Xiangrong (Texas A&M University, 2006-08-16)Lactate dehydrogenase A (LDHA) is hormonally regulated in rodents, and increased expression of LDHA is observed during mammary gland tumorigenesis. The mechanisms of hormonal regulation of LDHA were investigated in breast ...
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Avila, Luis Antonio de (Texas A&M University, 2005-11-01)Imazethapyr was recently approved for use in rice, but limited information is available regarding its efficacy, environmental fate or potential red rice resistance. Therefore, experiments were conducted to 1) determine the ...
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Hill, Denise Suzanne (2009-05-15)Neural tube defects (NTDs) are malformations affecting about 2.6/1000 births worldwide, and 1/1000 in the United States. Their etiology remains unknown, and is likely due to interaction of genetic susceptibility factors ...
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Cizmas, Leslie; Ackerman, Lani; Donnelly, Danielle A.; Donnelly, Kirby C.; McDonald, Thomas J. (Environmental and Analytical Toxicology, 2015-01-16)Although there are few published studies of residential exposures to environmental contaminants in Nepal, there may be substantial exposures to multiple contaminants in Nepali households. Pesticides, which can be harmful ...
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Cizmas, Leslie; Ackerman, Lani; Donnelly, Danielle A.; Donnelly, Kirby C.; McDonald, Thomas J. (Omics Publishing Group, 2015-01-16)Although there are few published studies of residential exposures to environmental contaminants in Nepal, there may be substantial exposures to multiple contaminants in Nepali households. Pesticides, which can be harmful ...
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Lee, Jeong Eun (Texas A&M University, 2006-04-12)In MCF7 and T47D cells cotreated with 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) plus 0.1-10 μM 3Â,4Â-dimethoxy flavone (DMF), there was a concentration-dependent decrease in the TCDD-induced ethoxyresorufin ...
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Dimitriou-Christidis, Petros (Texas A&M University, 2006-10-30)The biodegradability and physicochemical properties of unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) were investigated. The focus was on the development of models expressing the influence of molecular ...
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Dash, Bhagirathi (Texas A&M University, 2007-04-25)In this research, important stress and redox regulatory genes present in Hydra vulgaris were isolated and characterized to facilitate our understanding of the evolution and mechanisms of stress response. H. vulgaris heat ...
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Gu, Xinsheng (2009-05-15)Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is ...
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Zhang, Shu (2009-05-15)Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation and activation of kinase pathways in MCF-7 breast cancer cells. The role of estrogen receptor α (ERα) in mediating responses induced ...
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Afriyie-Gyawu, Evans (Texas A&M University, 2006-04-12)It is well documented that aflatoxin contamination in foods presents significant economic and public health burdens worldwide. Aflatoxins, particularly aflatoxin B1 (AFB1), have been implicated in the etiology of disease and ...