Browsing by Author "Safe, Stephen H."
Now showing items 21-40 of 50
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Li, Xiangrong (Texas A&M University, 2006-08-16)Lactate dehydrogenase A (LDHA) is hormonally regulated in rodents, and increased expression of LDHA is observed during mammary gland tumorigenesis. The mechanisms of hormonal regulation of LDHA were investigated in breast ...
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Howie, Laura Elizabeth (Texas A&M University. Libraries, 1992)The role of the aryl hydrocarbon (Ah) receptor in mediating the immunotoxic effects of several polychlorinated diphenyl ethers (PCDEs), polychlorinated biphenyls (PCBs), and alkyl-substituted polychlorinated dibenzofurans ...
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Zacharewski, Timothy Richard (Texas A&M University. Libraries, 1990)2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and related compounds elicit a broad range of biochemical and toxic responses. One aspect of this dissertation was to assess the utility of an in vitro induction bioassay ...
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Safe, Stephen H. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 1999-09-07)Provided in the present invention are compounds and compositions of substituted indole-3-carbinols and diindolylmethane suitable for treating estrogen-dependent tumors. Also provided are methods of treating such ...
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Reddivari, Lavanya (2009-05-15)The influence of genotype (selection), location, and year on antioxidant activity (AOA), total phenolics (TP), total carotenoids (TC), phenolic and carotenoid composition was studied using specialty (colored) potatoes ...
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Tan, Qiulin (Texas A&M University, 2006-04-12)Oxygen balance is very important and tightly regulated in mammals. Under hypoxia, hypoxia inducible factor 1(HIF-1) dimerizes with hypoxia inducible factor 1± (HIF-) and activates expression of several genes. Using a mammalian ...
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Walker, Kelcey Manae Becker (Texas A&M University, 2005-08-29)The aryl hydrocarbon receptor (AhR) binds synthetic and chemoprotective phytochemicals, and research in this laboratory has developed selective AhR modulators (SAhRMs) for treatment of breast cancer. Activation of the AhR ...
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Yao, Cheng Catsby (Texas A&M University. Libraries, 1989)Halogenated aryl hydrocarbon(HAH)-induced porphyria is caused by alteration of porphyrin metabolism and results in the accumulation of hepatic and urinary porphyrins. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (75 μg/kg) caused ...
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Hill, Denise Suzanne (2009-05-15)Neural tube defects (NTDs) are malformations affecting about 2.6/1000 births worldwide, and 1/1000 in the United States. Their etiology remains unknown, and is likely due to interaction of genetic susceptibility factors ...
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Merrill, Jill Christine (Texas A&M University. Libraries, 1987)Hymenoxys odorata (bitterweed) is an economically important poisonous range plant indigenous to the southwestern United States. The sesquiterpene lactone (SL), hymenoxon, has been isolated from bitterweed and demonstrated ...
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Cho, Sunggook Gook (2012-02-14)Activation of G-protein coupled receptor 54 (GPR54) signaling generated by kisspeptins (endogenous GPR54 ligands encoded by KISS1 gene) has been known to regulate puberty and to suppress cancer metastasis. However, an ...
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Lee, Jeong Eun (Texas A&M University, 2006-04-12)In MCF7 and T47D cells cotreated with 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) plus 0.1-10 μM 3Â,4Â-dimethoxy flavone (DMF), there was a concentration-dependent decrease in the TCDD-induced ethoxyresorufin ...
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Vanderlaag, Kathryn Elisabeth (2009-05-15)One in 8 women will be diagnosed with breast cancer in the United States and estrogen receptor (ER) status largely influences the type and subsequent success of treatment employed. Although ER-positive breast cancer can ...
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Lee, Wan-Ru (2009-05-15)The estrogen receptor (ER) is a ligand-activated transcription factor that regulates gene expression. The classical mechanisms of nuclear ER action include ligand-induced dimerization of ER which binds estrogen responsive ...
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Khan, Shaheen Munawar Ali (Texas A&M University, 2007-04-25)The CAD gene is trifunctional and expresses carbamoylphosphate synthetase/aspartate carbamyltransferase/dihydroorotase, which are required for pyrimidine biosynthesis. CAD gene activities are induced in MCF-7 human breast ...
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Chen, Chien-Cheng (2009-06-02)Estrogen receptor (ER) acts as a ligand-activated transcription factor that regulates the expression of genes. The genomic mechanisms of ER action include ligand-induced dimerization of ER which binds estrogen responsive ...
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Dash, Bhagirathi (Texas A&M University, 2007-04-25)In this research, important stress and redox regulatory genes present in Hydra vulgaris were isolated and characterized to facilitate our understanding of the evolution and mechanisms of stress response. H. vulgaris heat ...
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Sreevalsan, Sandeep (2013-05-31)Cancer is a growing health concern world-wide and is the second most common cause of death after heart diseases. Current treatment strategies such as surgery, chemotherapy and radiation provide some relief to cancer patients ...
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Jutooru, Indira Devi (2011-08-08)Methyl 2-cyano-3,11-dioxo-18b-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic triterpenoid that inhibits growth of Panc1 and Panc28 pancreatic cancer cell lines and activates peroxisome proliferator-activated receptor B ...
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Kelley, Michael Francis (Texas A&M University. Libraries, 1986)The mechanism of induction of cytochrome P-450 monooxygenasees by phenobarbital and a variety of structurally diverse xenobiotics (e.g., polyhalogenated biphenyls, organochlorine pesticides) is not well understood. Recently, ...