A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance
| dc.contributor.advisor | Wu, Chaodong | |
| dc.contributor.committeeMember | Morgan, Caurnel | |
| dc.contributor.committeeMember | Sturino, Joseph M | |
| dc.contributor.committeeMember | Awika, Joseph M | |
| dc.creator | Guo, Xin | |
| dc.date.accessioned | 2013-10-03T14:44:22Z | |
| dc.date.available | 2013-10-03T14:44:22Z | |
| dc.date.created | 2013-05 | |
| dc.date.issued | 2013-04-25 | |
| dc.date.submitted | May 2013 | |
| dc.date.updated | 2013-10-03T14:44:22Z | |
| dc.description.abstract | Overnutrition causes many metabolic diseases including type 2 diabetes. PFKFB3/iPFK2 is a master regulator of adipocyte and intestinal nutrient metabolism. Using PFKFB3/iPFK2+/– mice and adipocyte-specific PFKFB3 over-expression mice, the present study investigated the role of PFKFB3/iPFK2 in regulating diet-induced adiposity, inflammation in adipose tissue and intestine, and systemic insulin resistance. On a high-fat diet (HFD), PFKFB3+/– mice gained much less body weight than did wild-type littermates. However, HFD-induced systemic insulin resistance in PFKFB3+/– mice was more severe than in wild-type littermates. In contrast, adipocyte-specific PFKFB3 over-expression increased adiposity but suppressed overnutrition induced adipose tissue inflammatory response and improved insulin sensitivity. In addition to adipose tissue, PFKFB3/iPFK2 also played a role in intestine events. Compared to wild-type littermates, PFKFB3+/– mice displayed a significant increase in the expression of intestinal inflammatory markers on a HFD. In conclusion, PFKFB3 protects against overnutrition-induced adipose tissue and intestine inflammatory response and systemic insulin resistance in an adiposity-independent manner. Selective PFKFB3 activation may be viable for treating and/or preventing insulin resistance and type 2 diabetes. | en |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/149413 | |
| dc.language.iso | en | |
| dc.subject | PFKFB3/iPFK2 | en |
| dc.subject | Overnutrition | en |
| dc.subject | inflammatory response | en |
| dc.subject | insulin resistance | en |
| dc.title | A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance | en |
| dc.type | Thesis | en |
| dc.type.material | text | en |
| thesis.degree.department | Nutrition and Food Science | en |
| thesis.degree.discipline | Nutrition | en |
| thesis.degree.grantor | Texas A&M University | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |