S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

dc.contributor.assigneeThe Texas A&M University System
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorZingaro, Ralph A.
dc.creatorFreireich, Emil J.
dc.creatorDuzkale, Hatice
dc.creatorKantarjian, Hagop
dc.creatorVerstovsek, Srdan
dc.creatorSotelo-lerma, Merida
dc.date.accessioned2019-06-17T17:04:23Z
dc.date.available2019-06-17T17:04:23Z
dc.date.filed2006-02-06
dc.date.issued2009-11-17
dc.description.abstractArsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.en
dc.description.countryUS
dc.format.digitalOriginreformatted digitalen
dc.identifier.patentapplicationnumber11/349043
dc.identifier.urihttps://hdl.handle.net/1969.1/176905
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.publisher.digitalTexas A&M University. Libraries
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.subject.cpcprimaryA61P 35/00
dc.subject.cpcprimaryC07F 9/72
dc.subject.cpcprimaryA61P 35/02
dc.subject.uspcother424/629
dc.subject.uspcother556/71
dc.subject.uspcother556/77
dc.subject.uspcother556/78
dc.subject.uspcother556/80
dc.subject.uspcprimary514/504
dc.titleS-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for canceren
dc.typeUtility patenten

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