S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
dc.contributor.assignee | The Texas A&M University System | |
dc.contributor.assignee | Board of Regents, The University of Texas System | |
dc.creator | Zingaro, Ralph A. | |
dc.creator | Freireich, Emil J. | |
dc.creator | Duzkale, Hatice | |
dc.creator | Kantarjian, Hagop | |
dc.creator | Verstovsek, Srdan | |
dc.creator | Sotelo-lerma, Merida | |
dc.date.accessioned | 2019-06-17T17:04:23Z | |
dc.date.available | 2019-06-17T17:04:23Z | |
dc.date.filed | 2006-02-06 | |
dc.date.issued | 2009-11-17 | |
dc.description.abstract | Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity. | en |
dc.description.country | US | |
dc.format.digitalOrigin | reformatted digital | en |
dc.identifier.patentapplicationnumber | 11/349043 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176905 | |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.subject.cpcprimary | A61P 35/00 | |
dc.subject.cpcprimary | C07F 9/72 | |
dc.subject.cpcprimary | A61P 35/02 | |
dc.subject.uspcother | 424/629 | |
dc.subject.uspcother | 556/71 | |
dc.subject.uspcother | 556/77 | |
dc.subject.uspcother | 556/78 | |
dc.subject.uspcother | 556/80 | |
dc.subject.uspcprimary | 514/504 | |
dc.title | S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer | en |
dc.type | Utility patent | en |
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