Fusion Proteins (Seldegs) For Selectively Depleting Antigen-specific Antibodies And Methods Of Use Thereof
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Date
10/4/2022
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Publisher
United States. Patent and Trademark Office
Abstract
The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.