Characterization of oculomotor response to pseudorandom stimuli using time-domain analysis-effects of alcohol intoxication on smooth pursuit movements
Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Texas A&M University
Abstract
Oculomotor impairment is often a sign of brain dysfiinction. This study extends the effects of alcohol intoxication on the response of the smooth pursuit system to a pseudorandom non-linear sum-of-sinusoids input and attempts to develop mathematical regression models to represent the respo as recorded by infrared oculography (IROG). This study extends the work Reddy, using the data recorded from seventeen subjects in his experiments comparing the time-domain results to Reddy's nonlinear model. This work to determine the effects of introducing a time delay into a model simular the one developed by Reddy, using adjusted R2 values as the parameter of comparison. In addition, a difference between pre-and post-alcohol consumption recordings is investigated. Introducing time delays through use of lagged variables significantly improves the adjusted IC values of model. In fact, the first-order lagged variable improves the model more introducing higher-order non-lagged terms. The smooth pursuit system is strongly linear with minor non-linearities, as is shown through scatter p of the data and of first-order regression residuals. The R2values were observed for various values of lag in the first-order model and the maxim value obtained. The maximum occurred at different values of lag for each subject, indicating a wide amount of variation with a mean value of about 130ms, which has been reported in the literature. No statistically significant difference was found between the pre-and post-alcohol models suggesting that both conditions can be described by the same form of the model. This also implies that the sub-threshold alcohol level (BAC<0.10% not produce detectable manifestations.
Description
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Includes bibliographical references.
Issued also on microfiche from Lange Micrographics.
Includes bibliographical references.
Issued also on microfiche from Lange Micrographics.
Keywords
bioengineering., Major bioengineering.