Cardiac magnetic resonance imaging detects myocardial abnormalities in naturally infected dogs with chronic, asymptomatic Chagas disease

dc.creatorMatthews, Derek
dc.creatorFries, Ryan
dc.creatorJeffery, Nicholas
dc.creatorHamer, Sarah
dc.creatorSaunders, Ashley
dc.date.accessioned2023-04-15T04:34:25Z
dc.date.available2023-04-15T04:34:25Z
dc.date.issued2023-04-14
dc.description.abstractTrypanosoma cruzi infection causes inflammation and fibrosis, resulting in cardiac damage in dogs. The objectives of this study were to describe cardiac magnetic resonance imaging (CMR) in naturally infected dogs with chronic Chagas disease and the frequency of abnormalities for CMR and cardiac diagnostic tests. Ten asymptomatic, client-owned dogs seropositive for T. cruzi were prospectively enrolled in an observational study evaluating echocardiography, ECG (standard and ambulatory), cardiac troponin I (cTnI), and CMR. Standard ECG measurements (3/10) and cTnI concentration (1/10) outside the reference range were uncommon. Ambulatory ECG abnormalities were documented more frequently (6/10 dogs) than with standard ECG and included ventricular arrhythmias (4), supraventricular premature beats (3), second-degree atrioventricular block (2), and sinus arrest (1). Echocardiographic abnormalities were documented in 6/10 dogs including mildly increased left ventricular internal dimension in diastole (1) and decreased right ventricular (RV) systolic function based on reductions in tricuspid annular plane systolic excursion (3) and RV S’ (4). Abnormalities were detected with CMR in 7/10 dogs including delayed myocardial en-hancement in 5 of which 2 also had increased extracellular volume, abnormal wall motion in 5, and loss of apical compact myocardium in 1. In conclusion, CMR abnormalities were common, and the results of this study suggest CMR can provide useful information in dogs with T. cruzi in-fection and may support naturally infected dogs for future clinical investigation as an animal model for Chagas disease.en_US
dc.identifier.urihttps://hdl.handle.net/1969.1/197534
dc.language.isoen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTrypanosoma cruzien_US
dc.subjectChagas diseaseen_US
dc.subjectdogen_US
dc.subjectCardiac magnetic resonance imagingen_US
dc.titleCardiac magnetic resonance imaging detects myocardial abnormalities in naturally infected dogs with chronic, asymptomatic Chagas diseaseen_US
dc.typeDataseten_US
local.departmentSmall Animal Clinical Sciencesen_US

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