Polymer/copolymer nanoparticles conjugated to gambogic acid
| dc.contributor.assignee | The Texas A&M University System | |
| dc.creator | Majeti, Naga Venkata Ravi Kumar | |
| dc.creator | Ganugula, Raghu | |
| dc.creator | Arora, Meenakshi | |
| dc.creator | Saini, Prabhjot | |
| dc.date.accessioned | 2021-01-20T21:14:26Z | |
| dc.date.available | 2021-01-20T21:14:26Z | |
| dc.date.filed | 2016-07-27T00:00:00Z | |
| dc.date.issued | 2020-09-29T00:00:00Z | |
| dc.description.abstract | A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH.sub.2Cl.sub.2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH.sub.2Cl.sub.2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH.sub.2Cl.sub.2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives. | en |
| dc.description.country | US | |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.identifier.patentapplicationnumber | 15/748327 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/192116 | |
| dc.language | EN | |
| dc.publisher | United States. Patent and Trademark Office | |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.rights | Public Domain (No copyright - United States) | en |
| dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
| dc.subject.cpcprimary | A61K 9/5192 | |
| dc.subject.cpcprimary | A61K 9/5153 | |
| dc.subject.cpcprimary | A61K 47/549 | |
| dc.subject.cpcprimary | A61K 47/6937 | |
| dc.subject.cpcprimary | B82Y 30/00 | |
| dc.subject.cpcprimary | B82Y 5/00 | |
| dc.title | Polymer/copolymer nanoparticles conjugated to gambogic acid | en |
| dc.type | Utility patent | en |
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