Methodology for Studying Diffusion Through Polyelectrolyte Multilayers
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Date
2022-05-05
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Abstract
Polyelectrolyte multilayer membranes are a set of thin layer membranes fabricated using the layer-by-layer deposition of polyelectrolytes onto a given substrate. Thin films created on the surface of the modified substrates provide differences in material properties allowing their versatile application within the field of biomedical engineering. The multilayers are easily tunable depending on the simple modifications in thickness or composition of the coated PEMs layers and can aid materials in exhibiting favorable properties for loading and drug release of bioactive materials. Previously, the use of PEMs was explored to regulate the diffusion of glucose into a biosensing system. PEMs using polyelectrolyte layers of poly (allylamine hydrochloride) and poly (sodium-p-styrene sulfonate) allow transport limiting membrane required to increase the accuracy of glucose reading from the oxygen-sensitive fluorophores. [1] Altering the properties of the coated PEMs could alter the membrane diffusivity and device sensitivity to glucose. To design a methodology for the glucose biosensor, the modification of the PEMs composition, thickness, and crosslinking were applied to observe the effects on the diffusion characteristics. With the successful deposition of the thin film coating using the PAH and PSS multilayer composition, the layers were verified using contact angle measurements of the material surface. Subsequently, the diffusion of glucose across the differently layered PEMs was demonstrated to observe the decrease in diffusion rates across the fabricated PEMs layers with an increased membrane thickness.
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Layer-by-Layer, Polyelectrolyte Multilayers