Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD)

dc.contributor.advisorWu, Chaodong
dc.contributor.committeeMemberJi, Junyuan
dc.contributor.committeeMemberRiechman, Steven E.
dc.creatorGuo, Ting
dc.date.accessioned2015-09-21T17:02:17Z
dc.date.available2017-05-01T05:35:52Z
dc.date.created2015-05
dc.date.issued2015-05-08
dc.date.submittedMay 2015
dc.date.updated2015-09-21T17:02:17Z
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is currently a worldwide problem associated with diabetes, obesity, heart diseases, and insulin resistance. The pathogenesis of NAFLD is divided into simple steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and cirrhosis finally, lipid deposition and chronic inflammation are the main markers. There is still no effective medicine for the therapy of NAFLD, specifically in the NASH stage. Berberine (BBR) is a natural product isolated from plants such as Coptis chinensis Franch, and it has been reported it had beneficial pharmacological activities in a series of metabolic diseases, focusing on adenosine monophosphate-activated protein kinase (AMPK) pathway. BBR showed anti-hyperglycemic and anti-hyperlipidemic effects in diabetes and obesity patients and animal models. It improved insulin sensitivity in these reports and our experiment. We found BBR improved insulin resistance and glucose intolerance in HFD mice, without body weight or food intake difference. BBR ameliorates fat deposition in liver, through reducing lipogenesis related genes expression. Meanwhile, BBR decreased inflammation in liver and adipose tissue. BBR inhibited JNK pathway and activated AMPK phosphorylation in hepatocytes, but not in the macrophages. Thus, the function cells may be the main cell type that responds to BBR in liver, and maybe BBR down-regulates lipogenesis through inhibiting Akt.en
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/1969.1/155174
dc.language.isoen
dc.subjectNonalcoholic fatty liver diseaseen
dc.subjectberberineen
dc.subjectlipogenesisen
dc.subjectinflammationen
dc.subjecthigh-fat dieten
dc.subjectAMPKen
dc.subjectACCen
dc.subjectJNK 1en
dc.titleBeneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD)en
dc.typeThesisen
dc.type.materialtexten
local.embargo.terms2017-05-01
local.etdauthor.orcid0000-0002-3074-1278
thesis.degree.departmentNutrition and Food Scienceen
thesis.degree.disciplineNutritionen
thesis.degree.grantorTexas A & M Universityen
thesis.degree.levelMastersen
thesis.degree.nameMaster of Scienceen

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