Influence of Mechanical Conditions Driving Clinical Performance of Medical Device Constructs and Systems: A Dual-Study Approach in Human and Veterinary Fields for Optimization of the Clinical Outcome

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2017-12-11

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The work performed focused on the investigation of human and veterinary orthopedic devices. The work was accomplished in two parts and focused on different device aspects, with emphasis on biomechanical implications. Part I covers the design, development, and implementation of a novel joint motion replicator and was divided into two sections: (a) Joint Motion Replicator design and development, and (b) Joint Motion Replicator implementation in a toggle rod construct ex vivo study application. The replicator provides a dual-axis, closed-loop, stepper-controlled mechanical testing environment capable of reproducing physiologically relevant loading conditions and dynamic processes. Additionally, the ex vivo study compared biomechanical performance of three toggle rod fixation systems using cyclical testing protocols simulating flexion/extension and abduction/adduction. Part II of this work covers human implantable orthopedic devices, specifically devices used to treat fifth metatarsal base fractures located at the metaphyseal-diaphyseal watershed junction (Jones fractures). This project compares the biomechanical performance of a well-known intramedullary screw construct with a plantar-lateral plating construct applied to replicated Jones fractures in paired cadaver foot specimens.

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Biomedical Engineering, Orthopedics, Biomechanics

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