Mosaic chimeric viral vaccine particle
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Date
2020-11-17T00:00:00Z
Journal Title
Journal ISSN
Volume Title
Publisher
United States. Patent and Trademark Office
Abstract
The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.