Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof

Loading...
Thumbnail Image

Date

2021-06-22T00:00:00Z

Journal Title

Journal ISSN

Volume Title

Publisher

United States. Patent and Trademark Office

Abstract

The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.

Description

Keywords

Citation