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Near-infrared spectroscopy for the measurement of glucose in an integrated rotating wall vessel
| dc.creator | Galvan, Mark | |
| dc.date.accessioned | 2012-06-07T22:36:22Z | |
| dc.date.available | 2012-06-07T22:36:22Z | |
| dc.date.created | 1994 | |
| dc.date.issued | 1994 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-1994-THESIS-G182 | |
| dc.description | Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. | en |
| dc.description | Includes bibliographical references. | en |
| dc.description.abstract | In order to maximize cell culture growth in bioreactors, biosensors must be developed that are capable of monitoring the cell culture processes non-invasively and continuously. Current techniques used to monitor glucose concentration of cell culture media cannot fulfill these requirements. Therefore a near-infrared spectroscopy system is proposed that can potentially perform the required measurements on-line and without any interaction with the cell culture media. Two types of solutions with varying glucose concentrations were analyzed with the near-infrared spectroscopy system: a glucose and water solution and a bovine serum-based media known as GTSF-2. The results from the glucose and water solution showed the lowest achievable standard deviation of the residuals to be 100.5mg/dl with calibration with one set of data and validation with another set of data from a different day. The serum-based GTSF-2 media, however, seemed to provide an enhancement of the glucose signal despite its more complex formulation. The analysis of the GTSF-2 spectra produced a minimum standard deviation of the residuals of 68.35 mg/dl for analysis of two sets of spectra from the same day. Thus, near-infrared spectroscopy provides a means for glucose concentration measurement. | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.publisher | Texas A&M University | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.subject | bioengineering. | en |
| dc.subject | Major bioengineering. | en |
| dc.title | Near-infrared spectroscopy for the measurement of glucose in an integrated rotating wall vessel | en |
| dc.type | Thesis | en |
| thesis.degree.discipline | bioengineering | en |
| thesis.degree.name | M.S. | en |
| thesis.degree.level | Masters | en |
| dc.type.genre | thesis | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
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