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Lyme disease in an experimental mouse model
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|dc.description||Includes bibliographical references.||en|
|dc.description.abstract||This research was directed at developing a murine model for the investigation of Lyme disease. This study sought to define the route of inoculation necessary to establish infection or disease in susceptible C3H/HeJ mice and also, to determine the virulence of four Borrelia burgdorferi isolates. Further, the influence of MHC Class I and Class 11 genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. This thesis demonstrates the development of multisysternic infection in the mouse model, namely, dermatological, cardiac, and arthritic lesions in C3HJHeJ mouse. It also demonstrates the involvement of Class I genes (K and D regions) and Class 11 genes (I-A and I-E regions) of the mouse H-2 complex on the quantitative antibody titers. This was achieved by using genetically stable B IO congenic and recombinant strains. The data presented in this thesis strongly supports use of C3HJHeJ and BIO congenic and recombinant strains as potential laboratory animal models for Lyme disease research.||en|
|dc.publisher||Texas A&M University|
|dc.rights||This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use.||en|
|dc.title||Lyme disease in an experimental mouse model||en|
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