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dc.contributor.advisorByers, F. M.
dc.contributor.advisorHutcheson, D. P.
dc.creatorOrr, Carolyn Louise
dc.date.accessioned2020-08-21T21:56:54Z
dc.date.available2020-08-21T21:56:54Z
dc.date.issued1985
dc.identifier.urihttps://hdl.handle.net/1969.1/DISSERTATIONS-596446
dc.descriptionTypescript (photocopy).en
dc.description.abstractCrossbred male calves (225) with an average weight of 200 kg were used to investigate the metabolic response of feeder steers to the marketing and transportation (MT) processes and Infectious Bovine Rhinotracheitis virus (IBRV) infection. In trials 1 and 2, serum zinc (Zn), copper (Cu) and protein alterations occurring in calves naturally exposed to bacteria, viruses and stressors involved in bovine respiratory disease (BRD) were measured. Trial 3 and 4 were controlled studies with calves inoculated with IBRV, and acute phase response measured during the IBRV infection. Trial 4 calves were maintained in metabolism crates allowing daily urine and fecal collection and determination of nitrogen (N) balance. Mean serum Zn concentrations significantly decreased during BRD or IBRV infection, with lowest levels being when a calf first exhibited clinical morbidity. Serum Cu increased significantly as a result of either BRD or IBRV infection. Urinary Zn and Cu excretion increased significantly during IBRV infection in trial 4, indicating a greatly increased mobilization of metabolic copper. Serum protein patterns seen in all trials were similar with MT, BRD or IBRV stress causing an increase in total proteins, alpha and gamma globulins. Concomitant decreases in serum albumin and beta 2 globulins were observed. The degree of alteration in the serum protein pattern corresponded to the degree of morbidity observed. A significant increase in blood urea nitrogen, total bilirubin and a significant decrease in lactate dehydrogenase were observed as a result of IBRV infection. Nitrogen balance results indicated an increased excretion of urinary (17.9 vs 31.5 g/d) and fecal N (15.2 vs 24.2 g/d) resulting in a net loss of N during the fever of the IBRV infection in trial 4. Curve peeling analysis of %^15N excess/h (^15N) infusion data showed an increased catabolism (.218 vs .312 %^15N) and excretion of body N (.014 vs .026 %^15N), along with a decreased synthesis (.367 vs .189 %^15N) and half-life of ^15N (66.9 vs 48.3 h) as a result of the IBRV infection.en
dc.format.extentxi, 114 leavesen
dc.format.mediumelectronicen
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.rightsThis thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use.en
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectMajor animal scienceen
dc.subject.classification1985 Dissertation O75
dc.subject.lcshInfectious bovine rhinotracheitisen
dc.titleAcute phase response and body protein kinetics of bovine respiratory disease infected calvesen
dc.typeThesisen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.namePh. Den
dc.contributor.committeeMemberAnderson, J. G.
dc.contributor.committeeMemberThompson, G. B.
dc.type.genredissertationsen
dc.type.materialtexten
dc.format.digitalOriginreformatted digitalen
dc.publisher.digitalTexas A&M University. Libraries
dc.identifier.oclc16474918


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