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dc.contributor.advisorWortham, A. W.
dc.creatorLockhart, Robert Allen
dc.description.abstractSyntheses of nineteen new compounds are described, twelve of which are N-substituted derivatives of 1,2-benzisothiazolin-3-one-1,1-dioxide (saccharin): [structure]. New and improved syntheses of N-carboxymethyl-saccharin are reported; these procedures require short reaction time and give yields of 65-79%. Attention was focused on the study of two series: series 1 (n = 1-4, x = 3-(5,5-diphenylhydantionyl) and series 2 (n = 1-4, x = 3-(5,5-dimethyl-2,4-oxazolidine-dionyl). Spectral properties (mass, proton magnetic resonance, and infrared spectra) of these compounds were obtained and interpreted. Characteristic differences in the spectral details of ring and functional moieties allow easy identification of these compounds as well as products of biotransformation. When the above two series were screened for anticonbulsant activity, the compounds exhibited more versatility, though less effectiveness, than the parent anticonvulsants in protection against electrical and chemically-induced seizures in mice. For both series, compounds having two-carbon linkage showed maximum biological activity.en
dc.format.extent174 leavesen
dc.rightsThis thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use.en
dc.subject.classification1974 Dissertation L816
dc.titleSynthesis, spectra and anticonvulsant properties of saccharin derivativesen
dc.typeThesisen A&M Universityen of Philosophyen
dc.contributor.committeeMemberDrew, Dan D.
dc.contributor.committeeMemberElliott, Roger W.
dc.contributor.committeeMemberMeier, William L.
dc.contributor.committeeMemberRhyne, V. Thomas
dc.format.digitalOriginreformatted digitalen
dc.publisher.digitalTexas A&M University. Libraries

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