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dc.contributor.advisorVigh, Gyula
dc.creatorBusby, Michael Brent
dc.date.accessioned2006-08-16T19:01:24Z
dc.date.available2006-08-16T19:01:24Z
dc.date.created2005-05
dc.date.issued2006-08-16
dc.identifier.urihttp://hdl.handle.net/1969.1/3737
dc.description.abstractTwo novel, single-isomer, sulfated cyclodextrins, the sodium salts of heptakis(2- O-methyl-3-O-acetyl-6-O-sulfo)cyclomaltoheptaose (HMAS) and heptakis(2-O-methyl- 6-O-sulfo)cyclomaltoheptaose (HMS) were used as chiral resolving agents in both aqueous and non-aqueous electrophoretic separation of a set of pharmaceutically active weak base enantiomers. Enantiomers of twenty one of the twenty four weak bases were baseline resolved in one or more of the background electrolytes (BGE’s) used. An eight-step synthetic method was used to produce, on a large scale, the title compounds in greater than 97% purity. The purity of the synthetic intermediates and the final products were characterized by HPLC-ELSD and indirect UV-detection capillary electrophoresis (CE), respectively. X-ray crystallography, MALDI-TOF mass spectrometry and 1H as well as 13C NMR spectroscopy allowed for unambiguous characterization of the structure of each intermediate and the final product.en
dc.format.extent5579837 bytesen
dc.format.mediumelectronicen
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherTexas A&M University
dc.subjectheptakis(2-O-methyl-3-O-acetyl-6-O-sulfo)cyclomaltoheptaoseen
dc.subjectsingle-isomer sulfated cyclodextrinen
dc.subjectsulfated cyclodextrinen
dc.subjectenantiomer separationsen
dc.subjectcapillary electrophoresisen
dc.titleTwo new, single-isomer, sulfated β-cyclodextrins for use as chiral resolving agents for enantiomer separations in capillary electrophoresisen
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentChemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
dc.contributor.committeeMemberFord, David
dc.contributor.committeeMemberRaushel, Frank
dc.contributor.committeeMemberSoriaga, Manuel
dc.type.genreElectronic Dissertationen
dc.type.materialtexten
dc.format.digitalOriginborn digitalen


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