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Anticancer agents and use
(United States. Patent and Trademark Office, 2010-06-15)
Provided herein are compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl ...
Glycyrrhetinic acid derivatives
(United States. Patent and Trademark Office, 2013-03-05)
The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr ...
Beta-lactone compounds
(United States. Patent and Trademark Office, 2012-09-04)
The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof:
wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group ...
Compositions and methods for drug-sensitization or inhibition of a cancer cell
(United States. Patent and Trademark Office, 2018-01-16)
The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
Specific binding sites in collagen for integrins and use thereof
(United States. Patent and Trademark Office, 2019-07-23)
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising ...
Compounds and methods for the treatment of cancer
(United States. Patent and Trademark Office, 2012-07-17)
The present invention provides organic arsenicals which may be used to treat numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
Potent immunosuppressive agents, derivatives and uses
(United States. Patent and Trademark Office, 2014-09-23)
Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and ...
Belactosin derivatives as therapeutic agents/biological probes and their synthesis
(United States. Patent and Trademark Office, 2012-02-21)
Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, ...
C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
(United States. Patent and Trademark Office, 2012-04-03)
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 ?m. In addition, the ...
Cancer treatment targeting non-coding RNA overexpression
(United States. Patent and Trademark Office, 2015-02-17)
Provided herein are methods directed to modulating the pro-oncogenic effects of noncoding RNAs (ncRNAs) through their interactions with specificity protein transcription factors (SpTFs). In one aspect, the disclosure ...