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Organ-specific, multimodal, wireless optogenetics for high-throughput phenotyping of peripheral neural pathways
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In this study, I introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering eight individual home cages using a single radio-frequency transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies revealed an unexpected role for the stomach, non-stretch vagal sensory fibers in suppressing appetite, and demonstrated the durability of the miniature wireless device inside harsh gastric conditions. Together with an advanced machine learning algorithm and a novel switching mechanism, it enables experiments that can anatomically and physiologically map the functions of each targeted organ on the feeding control system in a freely behaving animal in a high-throughput manner.
gastric optoelectronic implant
multiplexing wireless telemetry
Kim, Woo Seok (2021). Organ-specific, multimodal, wireless optogenetics for high-throughput phenotyping of peripheral neural pathways. Doctoral dissertation, Texas A&M University. Available electronically from