DYNAMIC 31P MRS WITH A 1 TELSA EXTREMITY SCANNER
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^31P MRS offers unique non‐invasive access to investigate the in vivo metabolism and is a significant advancement in the understanding and treating of many disease processes. The challenge of in vivo dynamic ^31P MRS mainly originates from the relatively low concentration of phosphorus and the requirement of static magnetic field’s high homogeneity to distinguish the chemical shift of the peaks. Hence, conventional ^31P MRS is usually done in the high field / ultrahigh field whole-body MRI system equipped with multiple channels Bօ shimming coil. On the other hand, extremity NMR scanners which usually have low (<0.5T) or medium (0.5-1T) field strength are often available for a relatively low cost. Those limitations make high temporal resolution dynamic ^31P MRS difficulty using conventional NMR signal acquisition technology in extremity NMR scanners. We propose here using a four-element coil receive-only array and a transmit-only birdcage to investigate the possibility of dynamic ^31P MRS in a 1T ONI extremity scanner. NMR phased array simultaneously acquires multiple channels’ signal from non-interacting receive coils array and subsequently combines the data. In the condition of a poor shimming magnet, another improvement of spectral peak linewidth by replacing single channels coil with multiple smaller channels coils is also studied. A legible spectral is obtained from in vivo volunteers with 4-16 averages, which gives us 16s-64s temporal resolution. The array coil combined SNR is found to be 1.8 times better than using a single loop as a receive coil of the same overall size, and linewidth is improved from 0.72 to 0.45 ppm. This platform shows the potential for monitoring ^31P in vivo metabolism with meaningful temporal resolution in an easy instrument outside of the hospital environment.
Gu, Minyu (2019). DYNAMIC 31P MRS WITH A 1 TELSA EXTREMITY SCANNER. Master's thesis, Texas A&M University. Available electronically from