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dc.creatorReddy, Doodipala Samba
dc.date.accessioned2019-06-17T17:15:22Z
dc.date.available2019-06-17T17:15:22Z
dc.date.issued2019-01-08
dc.identifier.urihttp://hdl.handle.net/1969.1/177276
dc.description.abstractThe present invention provides new compositions and methods for treating and/or reversing organophosphate intoxication, manifested by both cholinergic and non-cholinergic crisis, in a mammal resulting from exposure to organophosphate compounds. The neurosteroidal compounds of this invention are those having the general structural formula of pregnane, androstane, 19-norandrostanes, and norpregnane with further moieties as defined herein. These compounds include, but are not limited to, ganaxolone, pregnanolone, and androstanediol and their analogs, salts and prodrugs. The present invention further relates to combining a therapeutically effective amount of a neurosteroidal compound with a standard organophosphate antidote (e.g. atropine, pralidoxime). The data suggests that neurosteroids are effective or more effective than benzodiazepines, whether given earlier or later than 40-min (up to several hours) after organophosphate compound exposure. Neurosteroids are effective to attenuate long-term neuropsychiatric deficits caused by organophosphate exposure.en
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.titleMethod of treating organophosphate intoxication by administration of neurosteroidsen
dc.typeUtility patenten
dc.format.digitalOriginreformatted digitalen
dc.description.countryUS
dc.contributor.assigneeTHE Texas A&M UNIVERSITY SYSTEM
dc.identifier.patentapplicationnumber15/508233
dc.date.filed2015-09-01
dc.publisher.digitalTexas A&M University. Libraries
dc.subject.cpcprimaryA61K 31/57


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